Protein: MED15
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)

Gene: MED15
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q96RN5

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1401572

MED29
Mediator of RNA polymerase II transcription subunit 29

4

2

High-throughput

0.903

High

1401577

MED23
Mediator of RNA polymerase II transcription subunit 23

4

4

Small-scale

0.886

High

1401578

MED16
Mediator of RNA polymerase II transcription subunit 16

3

1

Small-scale

0.827

High

881589

CDK8
Cyclin-dependent kinase 8

14

14

Small-scale

0.762

High

49004

MED19
Mediator of RNA polymerase II transcription subunit 19

7

1

High-throughput

0.750

High

282411

MED24
Mediator of RNA polymerase II transcription subunit 24

2

0

High-throughput

0.748

High

1151283

MED1
Mediator of RNA polymerase II transcription subunit 1

7

12

Small-scale

0.746

High

1401565

CDK19
Cyclin-dependent kinase 19

6

13

Small-scale

0.733

High

787893

SRBP1
Sterol regulatory element-binding protein 1

5

20

Small-scale

0.721

High

219507

MED7
Mediator of RNA polymerase II transcription subunit 7

5

4

Small-scale

0.718

High

1401569

MED4
Mediator of RNA polymerase II transcription subunit 4

5

2

High-throughput

0.716

High

1372181

MED12
Mediator of RNA polymerase II transcription subunit 12

5

15

Small-scale

0.714

High

666893

CCNC
Cyclin-C

5

6

High-throughput

0.706

High

1108387

MED21
Mediator of RNA polymerase II transcription subunit 21

4

2

High-throughput

0.697

High

336023

MED26
Mediator of RNA polymerase II transcription subunit 26

4

1

Small-scale

0.694

High

1401563

MED10
Mediator of RNA polymerase II transcription subunit 10

4

2

Small-scale

0.694

High

1401564

MED18
Mediator of RNA polymerase II transcription subunit 18

4

1

High-throughput

0.694

High

239608

MED14
Mediator of RNA polymerase II transcription subunit 14

4

20

Small-scale

0.686

High

1401566

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.684

High

1401570

MED17
Mediator of RNA polymerase II transcription subunit 17

4

1

Small-scale

0.683

High

1401568

MED20
Mediator of RNA polymerase II transcription subunit 20

3

1

High-throughput

0.667

High

1401571

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

High-throughput

0.664

High

1390283

TRI11
E3 ubiquitin-protein ligase TRIM11

3

10

Small-scale

0.650

High

1401575

MED13
Mediator of RNA polymerase II transcription subunit 13

3

2

Small-scale

0.650

High

287813

MED6
Mediator of RNA polymerase II transcription subunit 6

3

2

Small-scale

0.640

High

1259270

MED25
Mediator of RNA polymerase II transcription subunit 25

3

3

Small-scale

0.640

High

927506

ATX1
Ataxin-1

2

4

High-throughput

0.628

High

1149703

MED22
Mediator of RNA polymerase II transcription subunit 22

2

1

High-throughput

0.611

High

1241404

MED27
Mediator of RNA polymerase II transcription subunit 27

2

1

High-throughput

0.611

High

1401573

MED11
Mediator of RNA polymerase II transcription subunit 11

2

1

High-throughput

0.611

High

1401579

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.602

High

1153879

SMAD2
Mothers against decapentaplegic homolog 2

2

20

Small-scale

0.601

High

843891

HD
Huntingtin

2

4

High-throughput

0.596

High

260334

BRD4
Bromodomain-containing protein 4

2

14

High-throughput

0.584

High

1087963

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

1114073

CUL3
Cullin-3

2

12

High-throughput

0.584

High

396760

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

180575

PLS1
Phospholipid scramblase 1

1

4

High-throughput

0.541

High

936569

AF17
Protein AF-17

1

4

High-throughput

0.541

High

1116569

FHL3
Four and a half LIM domains protein 3

1

14

High-throughput

0.541

High

123808

MYO1C
Unconventional myosin-Ic

1

7

High-throughput

0.536

High

518895

CCL3
C-C motif chemokine 3

1

1

High-throughput

0.536

High

957822

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

3

High-throughput

0.536

High

1053381

CTSL2
CTD small phosphatase-like protein 2

1

3

High-throughput

0.536

High

1161367

HIF1A
Hypoxia-inducible factor 1-alpha

1

20

Small-scale

0.536

High

1243765

FXL19
F-box/LRR-repeat protein 19

1

6

High-throughput

0.536

High

1347841

RIN3
Ras and Rab interactor 3

1

9

High-throughput

0.536

High

1393372

MED30
Mediator of RNA polymerase II transcription subunit 30

1

2

High-throughput

0.536

High

887146

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.527

High

784696

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.518

High

1014586

SMAD3
Mothers against decapentaplegic homolog 3

1

20

Small-scale

0.515

High

1039554

TOP2B
DNA topoisomerase 2-beta

1

6

High-throughput

0.515

High

1153996

SMAD1
Mothers against decapentaplegic homolog 1

1

20

Small-scale

0.515

High

959038

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

976137

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

1045669

TF65
Transcription factor p65

1

20

Small-scale

0.501

High

1401581

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

3

Small-scale

0.501

High

1085462

SRBP2
Sterol regulatory element-binding protein 2

1

20

Small-scale

0.500

High

1401580

TRRAP
Transformation/transcription domain-associated protein

1

9

Small-scale

0.484

High

143207

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

186794

P73
Tumor protein p73

1

16

Small-scale

0.479

High

210097

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

283535

TAD2A
Transcriptional adapter 2-alpha

1

12

High-throughput

0.479

High

341655

EYA4
Protein phosphatase EYA4

1

18

High-throughput

0.479

High

404353

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

474228

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

508474

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

Small-scale

0.479

High

520307

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

551211

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.479

High

601819

HMGA1
High mobility group protein HMG-I/HMG-Y

1

4

High-throughput

0.479

High

696272

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

714365

PML
Protein PML

1

15

High-throughput

0.479

High

768949

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

862394

YAP1
Transcriptional coactivator YAP1

1

19

High-throughput

0.479

High

920212

PLK1
Serine/threonine-protein kinase PLK1

1

10

High-throughput

0.479

High

935028

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.479

High

1033168

EWS
RNA-binding protein EWS

1

12

High-throughput

0.479

High

1048070

TLE3
Transducin-like enhancer protein 3

1

16

High-throughput

0.479

High

1088982

TP53B
TP53-binding protein 1

1

12

High-throughput

0.479

High

1103329

CTBP1
C-terminal-binding protein 1

1

8

High-throughput

0.479

High

1106674

SMAD4
Mothers against decapentaplegic homolog 4

1

20

Small-scale

0.479

High

1108062

SQSTM
Sequestosome-1

1

7

High-throughput

0.479

High

1120298

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

14

Small-scale

0.479

High

1133619

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1134810

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

20

High-throughput

0.479

High

1141273

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1151376

TRIP4
Activating signal cointegrator 1

1

2

High-throughput

0.479

High

1212023

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

9

High-throughput

0.479

High

1255157

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1257808

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.479

High

1259062

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

2

High-throughput

0.479

High

1276674

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1289278

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

8

High-throughput

0.479

High

1313036

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

1339144

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

1357525

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1367074

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1380102

FBXW7
F-box/WD repeat-containing protein 7

1

8

Small-scale

0.479

High

1391329

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

High-throughput

0.479

High

1400058

QKI
KH domain-containing RNA-binding protein QKI

1

5

High-throughput

0.479

High

1401562

EPAS1
Endothelial PAS domain-containing protein 1

1

20

Small-scale

0.479

High

1401574

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1401576

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

401336

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.445

High

537749

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.445

High

352636

TCL1B
T-cell leukemia/lymphoma protein 1B

1

1

High-throughput

0.437

High

1227307

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.437

High

1295670

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

19

High-throughput

0.437

High

95753

E5RFK5
Cyclin-C

1

6

High-throughput

0.407

High

1401567

AL8A1
2-aminomuconic semialdehyde dehydrogenase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025