HitPredict

Interactor 1: SPT5H (O00267)
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)
Gene: SUPT5H

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29395067
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1087 Hs			1 3969
+	Hs
		975285 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		975298 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		123953 SPT5H_HUMAN (1-1087): 0: 1061: 100.00		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		124057 SPT5H_HUMAN (1-1087): 0: 1061: 100.00		MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18
+	Hs
		123781 SPT5H_HUMAN (1-1087): 0: 1061: 100.00		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Dm
		594809 SPT5H_DROME (64-1084): 0: 828: 51.79		TRX_DROME (3633-3969): 3.49e-71: 270: 43.54
+	Sc
		650325 SPT5_YEAST (5-944): 0: 594: 23.73		SET2_YEAST (3811-3968): 1.56e-56: 214: 29.56
+	Hs
		1243852 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		554310 MUC1_HUMAN (746-971): 1.34e-11: 71: 16.30		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1080127 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Dm
		375641 RPB1_DROME (765-1072): 8.42e-11: 68.8: 12.35		TRX_DROME (3633-3969): 3.49e-71: 270: 43.54
+	Hs
		1243853 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12
+	Hs
		165699 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		165705 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Mm
		444974 RPB1_MOUSE (802-916): 3.3e-09: 63.3: 20.00		NSD2_MOUSE (3752-3968): 6.91e-55: 215: 27.68
+	Mm
		1351630 PCLO_MOUSE (622-1063): 7.05e-09: 62.6: 11.82		PCLO_MOUSE (755-1426): 4.31e-12: 75.3: 12.23
+	Hs
		152667 KMT2C_HUMAN (634-1078): 3.48e-09: 63.4: 13.80		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		152675 CBP_HUMAN (747-1035): 5.79e-09: 62.6: 12.81		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47