HitPredict

Interactor 1: Q6PK50 (Q6PK50)
HSP90AB1 protein
Gene: HSP90AB1

Interactor 2: Q9BPW0 (Q9BPW0)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Metallophos, HSP90~PPP5, HSP90~TPR_1
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 351 Hs			1 484
+	Hs
		468210 HS90B_HUMAN (1-345): 6.02e-174: 502: 100.00		PPP5_HUMAN (1-482): 0: 544: 99.17
+	Mm
		547256 HS90B_MOUSE (1-345): 8.6e-175: 504: 99.71		PPP5_MOUSE (1-482): 0: 539: 96.89
+	Hs
		117618 K9JA46_HUMAN (1-350): 4.37e-172: 498: 84.92		PPP5_HUMAN (1-482): 0: 544: 99.17
+	Hs
		461300 HS90A_HUMAN (1-350): 4.37e-172: 498: 84.92		PPP5_HUMAN (1-482): 0: 544: 99.17
+	Mm
		462116 HS90A_MOUSE (1-350): 7.92e-172: 497: 84.12		PPP5_MOUSE (1-482): 0: 539: 96.89
+	Mm
		465815 ENPL_MOUSE (2-351): 3.27e-139: 415: 41.97		PPP5_MOUSE (1-482): 0: 539: 96.89
+	Hs
		916666 H90B4_HUMAN (25-328): 1.55e-133: 392: 83.22		PPP5_HUMAN (1-482): 0: 544: 99.17
+	Sc
		578884 HSC82_YEAST (13-350): 7.72e-146: 430: 65.49		PP2A1_YEAST (160-484): 4.05e-169: 482: 36.50
+	Sc
		393044 HSP82_YEAST (11-350): 7.75e-147: 432: 66.86		PPP5_YEAST (18-481): 1.25e-163: 474: 37.02
+	Sc
		579747 HSC82_YEAST (13-350): 7.72e-146: 430: 65.49		PPP5_YEAST (18-481): 1.25e-163: 474: 37.02
+	Dm
		1345490 Q9VAY2_DROME (4-350): 6.96e-138: 412: 45.33		Q8T0U6_DROME (142-477): 1.76e-166: 479: 34.22
+	Sc
		579066 HSC82_YEAST (13-350): 7.72e-146: 430: 65.49		PP12_YEAST (204-479): 1.35e-149: 431: 40.07
+	Dm
		873607 Q9VAY2_DROME (4-350): 6.96e-138: 412: 45.33		PP1B_DROME (186-482): 3.55e-150: 432: 36.24
+	Hs
		916682 Q86SX1_HUMAN (1-135): 3.67e-78: 242: 88.57		PPP5_HUMAN (1-482): 0: 544: 99.17