HitPredict

Interactor 1: RUFY4 (Q6ZNE9)
RUN and FYVE domain-containing protein 4
Gene: RUFY4

Interactor 2: MLP3C (Q9BXW4)
Microtubule-associated protein 1 light chain 3 gamma (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (Microtubule-associated proteins 1A/1B light chain 3C) (MAP1A/MAP1B LC3 C) (MAP1A/MAP1B light chain 3 C)
Gene: MAP1LC3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000045 - autophagosome assembly GO:0005776 - autophagosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 571 Hs			1 147
+	Hs
		328205 PKHM1_HUMAN (4-547): 6.85e-71: 248: 16.41		GBRAP_HUMAN (13-127): 3.46e-54: 168: 38.26
+	Hs
		1428438 PKHM1_HUMAN (4-547): 6.85e-71: 248: 16.41		MLP3B_HUMAN (7-127): 8.19e-53: 164: 54.55
+	Hs
		1316767 WDFY3_HUMAN (344-569): 5.36e-33: 137: 13.33		MLP3C_HUMAN (1-147): 4.66e-72: 214: 100.00
+	Dm
		1481827 Q9VML2_DROME (232-569): 4.08e-40: 159: 11.97		Q9W2S2_DROME (13-127): 6.16e-55: 170: 37.39
+	Hs
		1410935 FYCO1_HUMAN (106-568): 2.06e-22: 104: 11.44		MLP3C_HUMAN (1-147): 4.66e-72: 214: 100.00
+	Hs
		1233684 WDFY3_HUMAN (344-569): 5.36e-33: 137: 13.33		Q6IAW1_HUMAN (13-127): 3.46e-54: 168: 38.26
+	Hs
		328068 WDFY3_HUMAN (344-569): 5.36e-33: 137: 13.33		GBRAP_HUMAN (13-127): 3.46e-54: 168: 38.26
+	Hs
		952240 WDFY3_HUMAN (344-569): 5.36e-33: 137: 13.33		GBRL2_HUMAN (13-126): 1.66e-54: 168: 42.98
+	Mm
		1250544 WDFY3_MOUSE (344-569): 8.38e-34: 139: 12.96		MLP3A_MOUSE (7-126): 2.5e-53: 165: 59.17
+	Hs
		1316773 WDFY3_HUMAN (344-569): 5.36e-33: 137: 13.33		MLP3A_HUMAN (7-126): 2.5e-53: 165: 59.17
+	Hs
		1316768 WDFY3_HUMAN (344-569): 5.36e-33: 137: 13.33		MLP3B_HUMAN (7-127): 8.19e-53: 164: 54.55
+	Hs
		1316770 WDFY3_HUMAN (344-569): 5.36e-33: 137: 13.33		GBRL1_HUMAN (13-126): 4.78e-52: 162: 39.47
+	Hs
		327782 DESP_HUMAN (154-523): 1.83e-28: 123: 10.27		GBRAP_HUMAN (13-127): 3.46e-54: 168: 38.26
+	Hs
		587605 DESP_HUMAN (154-523): 1.83e-28: 123: 10.27		GBRL2_HUMAN (13-126): 1.66e-54: 168: 42.98
+	Hs
		1428391 MTMR4_HUMAN (393-564): 6.7e-29: 124: 13.89		MLP3B_HUMAN (7-127): 8.19e-53: 164: 54.55
+	Hs
		587803 DESP_HUMAN (154-523): 1.83e-28: 123: 10.27		MLP3A_HUMAN (7-126): 2.5e-53: 165: 59.17
+	Hs
		587797 DESP_HUMAN (154-523): 1.83e-28: 123: 10.27		MLP3B_HUMAN (7-127): 8.19e-53: 164: 54.55
+	Hs
		587800 DESP_HUMAN (154-523): 1.83e-28: 123: 10.27		GBRL1_HUMAN (13-126): 4.78e-52: 162: 39.47
+	Hs
		328134 FYCO1_HUMAN (106-568): 2.06e-22: 104: 11.44		GBRAP_HUMAN (13-127): 3.46e-54: 168: 38.26
+	Hs
		952320 FYCO1_HUMAN (106-568): 2.06e-22: 104: 11.44		GBRL2_HUMAN (13-126): 1.66e-54: 168: 42.98