Protein: PKHM1
Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)

Gene: PKHM1, PLEKHM1
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q9Y4G2

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005764 - lysosome
GO:0008270 - zinc ion binding
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

901709

RAB7A
Ras-related protein Rab-7a

6

20

Small-scale

0.946

High

1450649

ARL8B
ADP-ribosylation factor-like protein 8B

2

12

Small-scale

0.815

High

888824

VPS41
Vacuolar protein sorting-associated protein 41 homolog

4

4

Small-scale

0.703

High

1454287

VPS18
Vacuolar protein sorting-associated protein 18 homolog

3

3

Small-scale

0.674

High

1383725

VP33A
Vacuolar protein sorting-associated protein 33A

3

1

Small-scale

0.656

High

1431606

VPS11
Vacuolar protein sorting-associated protein 11 homolog

3

3

Small-scale

0.656

High

1147512

RHEB
GTP-binding protein Rheb

1

10

Small-scale

0.618

High

328205

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

8

Small-scale

0.611

High

562513

LAMP2
Lysosome-associated membrane glycoprotein 2

2

10

Small-scale

0.611

High

1233608

LTOR1
Ragulator complex protein LAMTOR1

2

8

Small-scale

0.611

High

1394874

VPS39
Vam6/Vps39-like protein

2

4

Small-scale

0.611

High

839415

MTOR
Serine/threonine-protein kinase mTOR

1

4

Small-scale

0.586

High

959431

RAP1B
Ras-related protein Rap-1b

1

10

Small-scale

0.553

High

895510

SPB9
Serpin B9

1

2

High-throughput

0.541

High

1419276

TRI54
Tripartite motif-containing protein 54

1

6

High-throughput

0.541

High

1428925

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

2

High-throughput

0.541

High

189950

STX7
Syntaxin-7

1

3

Small-scale

0.536

High

540772

LAMP1
Lysosome-associated membrane glycoprotein 1

1

10

Small-scale

0.536

High

938306

SEC13
Protein SEC13 homolog

1

3

Small-scale

0.536

High

1219793

RRAGB
Ras-related GTP-binding protein B

1

1

Small-scale

0.536

High

1245345

WDR59
GATOR2 complex protein WDR59

1

3

Small-scale

0.536

High

1272168

RRAGA
Ras-related GTP-binding protein A

1

1

Small-scale

0.536

High

1322682

RPTOR
Regulatory-associated protein of mTOR

1

6

Small-scale

0.536

High

1388917

SEH1
Nucleoporin SEH1

1

3

Small-scale

0.536

High

1415170

LST8
Target of rapamycin complex subunit LST8

1

1

Small-scale

0.536

High

1451959

MIOS
GATOR2 complex protein MIOS

1

1

Small-scale

0.536

High

627742

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.518

High

890914

TSC2
Tuberin

1

0

Small-scale

0.513

High

908068

VAMP7
Vesicle-associated membrane protein 7

1

0

Small-scale

0.513

High

1247058

RICTR
Rapamycin-insensitive companion of mTOR

1

0

Small-scale

0.513

High

1409810

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

Small-scale

0.513

High

1431594

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

Small-scale

0.513

High

1459048

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

Small-scale

0.513

High

1490863

LTOR2
Ragulator complex protein LAMTOR2

1

0

Small-scale

0.513

High

1161279

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.508

High

703755

MK01
Mitogen-activated protein kinase 1

1

0

Small-scale

0.480

High

1252612

DEFI8
Differentially expressed in FDCP 8 homolog

1

4

Small-scale

0.479

High

1428229

NDEL1
Nuclear distribution protein nudE-like 1

1

5

Small-scale

0.479

High

1335341

FA98A
Protein FAM98A

1

0

Small-scale

0.458

High

1461787

TPX2
Targeting protein for Xklp2

1

0

Small-scale

0.458

High

1428438

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

8

Small-scale

0.439

High

1415829

KIFC1
Kinesin-like protein KIFC1

1

2

Small-scale

0.437

High

1398897

RILP
Rab-interacting lysosomal protein

1

0

Small-scale

0.426

High

1142471

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

1

0

High-throughput

0.282

High

1491113

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.282

High

1091916

NPRL3
GATOR1 complex protein NPRL3

1

0

Small-scale

0.279

Low

1236099

PRR5L
Proline-rich protein 5-like

1

0

Small-scale

0.279

Low

1462329

STX8
Syntaxin-8

1

0

Small-scale

0.279

Low

332193

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

0

High-throughput

0.265

Low

939667

BID
BH3-interacting domain death agonist

1

0

High-throughput

0.265

Low

214084

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.249

Low

1452239

NSMA2
Sphingomyelin phosphodiesterase 3

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025