HitPredict

Interactor 1: LEG9 (O00182)
Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)
Gene: LGALS9

Interactor 2: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0010629 - negative regulation of gene expression
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 355 Hs			1 4544
+	Hs
		480773 LEG1_HUMAN (234-353): 4.62e-34: 124: 32.00		LRP1_HUMAN (24-4544): 0: 3504: 100.00
+	Hs
		125448 LEG9_HUMAN (1-355): 3.81e-147: 421: 100.00		NID2_HUMAN (1679-1844): 1.09e-11: 74.1: 24.86
+	Hs
		125551 LEG9_HUMAN (1-355): 3.81e-147: 421: 100.00		SORL_HUMAN (1080-1344): 6.87e-10: 68.3: 13.65
+	Hs
		125198 LEG9_HUMAN (1-355): 3.81e-147: 421: 100.00		NID1_HUMAN (3259-3502): 3.72e-09: 65.6: 13.18
+	Hs
		127382 LEG8_HUMAN (1-355): 1.79e-106: 316: 30.85		SORL_HUMAN (1080-1344): 6.87e-10: 68.3: 13.65
+	Hs
		609676 LEG3_HUMAN (5-147): 7.97e-42: 148: 38.00		NID2_HUMAN (1679-1844): 1.09e-11: 74.1: 24.86
+	Hs
		868688 LEG7_HUMAN (224-354): 5.44e-41: 142: 37.04		NID2_HUMAN (1679-1844): 1.09e-11: 74.1: 24.86
+	Hs
		572678 LEG3_HUMAN (5-147): 7.97e-42: 148: 38.00		NID1_HUMAN (3259-3502): 3.72e-09: 65.6: 13.18
+	Hs
		480790 LEG1_HUMAN (234-353): 4.62e-34: 124: 32.00		NID2_HUMAN (1679-1844): 1.09e-11: 74.1: 24.86
+	Hs
		480767 LEG1_HUMAN (234-353): 4.62e-34: 124: 32.00		LRP2_HUMAN (2-286): 2.25e-10: 69.9: 13.86
+	Hs
		480869 LEG1_HUMAN (234-353): 4.62e-34: 124: 32.00		SORL_HUMAN (1080-1344): 6.87e-10: 68.3: 13.65
+	Hs
		376465 LEG1_HUMAN (234-353): 4.62e-34: 124: 32.00		LDLR_HUMAN (4098-4307): 8.05e-10: 67.6: 13.72
+	Hs
		480677 LEG1_HUMAN (234-353): 4.62e-34: 124: 32.00		NID1_HUMAN (3259-3502): 3.72e-09: 65.6: 13.18
+	Hs
		287514 LEG1_HUMAN (234-353): 4.62e-34: 124: 32.00		LRP6_HUMAN (1068-1243): 9.55e-09: 64.5: 21.62