Interactor 1: TLR4 (O00206)
Toll-like receptor 4 (hToll) (CD antigen CD284)
Gene: TLR4
Interactor 2: TCAM2 (Q86XR7)
TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4)
Gene: TICAM2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.93 | 0.60 | 0.747 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25736436, 31511519, 17258210, 18221795, 21903422, 21829704, 22139835, 24265315 |
| Identification Methods | affinity chromatography technology, protein complementation assay, anti tag coimmunoprecipitation, mammalian protein protein interaction trap |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0001891 - phagocytic cup GO:0005769 - early endosome GO:0005886 - plasma membrane GO:0006909 - phagocytosis GO:0006954 - inflammatory response and 6 others more... |
| Homologous interactions | 8 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
