HitPredict

Interactor 1: VPP1 (Q93050)
V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)
Gene: ATP6V0A1

Interactor 2: VATD (Q9Y5K8)
V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)
Gene: ATP6V1D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

The method score is based on:

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007035 - vacuolar acidification GO:0007042 - lysosomal lumen acidification and 10 others more... GO:0010008 - endosome membrane GO:0016020 - membrane GO:0016241 - regulation of macroautophagy GO:0030665 - clathrin-coated vesicle membrane GO:0033176 - proton-transporting V-type ATPase complex GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:0048388 - endosomal lumen acidification GO:0070062 - extracellular exosome GO:0097401 - synaptic vesicle lumen acidification GO:1902600 - proton transmembrane transport
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	837
Hs

1	247

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024