HitPredict

Interactor 1: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Interactor 2: UBP25 (Q9UHP3)
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
Gene: USP25

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.50	0.512

Property	Details
Experiments	35171955
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 540 Hs			1 1055
+	Hs
		1278081 MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00		UBP28_HUMAN (1-1047): 0: 897: 48.43
+	Hs
		1129707 MDC1_HUMAN (79-450): 8.81e-11: 67.1: 13.06		UBP28_HUMAN (1-1047): 0: 897: 48.43
+	Hs
		967157 MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00		UBP46_HUMAN (159-470): 4.87e-85: 281: 17.16
+	Hs
		1257911 HUWE1_HUMAN (79-539): 2.9e-23: 106: 13.36		UBP34_HUMAN (132-425): 1.83e-73: 269: 22.11
+	Hs
		1278148 MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00		UBP22_HUMAN (460-661): 1.14e-19: 96.1: 17.82
+	Hs
		288448 MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00		UBP2_HUMAN (514-655): 1.22e-14: 80.4: 18.31
+	Hs
		275902 MAVS_HUMAN (1-540): 6.17e-72: 240: 100.00		UBP12_HUMAN (465-658): 2.29e-09: 62.6: 16.83
+	Mm
		92768 D3Z656_MOUSE (196-533): 9.1e-09: 60.6: 8.64		UBP48_MOUSE (157-406): 1.11e-64: 240: 25.86
+	Hs
		1280386 HUWE1_HUMAN (79-539): 2.9e-23: 106: 13.36		USP9X_HUMAN (142-405): 3.02e-43: 174: 20.85
+	Mm
		1230534 MAVS_MOUSE (1-538): 3.91e-43: 162: 47.68		UBP7_MOUSE (547-758): 7.25e-18: 91.4: 22.22
+	Hs
		1129699 MDC1_HUMAN (79-450): 8.81e-11: 67.1: 13.06		UBP47_HUMAN (163-418): 1.84e-39: 161: 18.45
+	Hs
		1280387 HUWE1_HUMAN (79-539): 2.9e-23: 106: 13.36		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78
+	Mm
		1230402 HUWE1_MOUSE (108-539): 5.17e-18: 90.3: 13.89		UBP7_MOUSE (547-758): 7.25e-18: 91.4: 22.22
+	Mm
		97714 E9PWQ7_MOUSE (46-526): 7.04e-13: 74.1: 11.38		UBP7_MOUSE (547-758): 7.25e-18: 91.4: 22.22
+	Hs
		1129678 MDC1_HUMAN (79-450): 8.81e-11: 67.1: 13.06		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78
+	Hs
		1371764 MAGL2_HUMAN (44-521): 5.97e-10: 64.4: 11.55		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78
+	Hs
		1371709 MAGE1_HUMAN (107-434): 3.63e-09: 61.7: 16.42		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78