HitPredict

Interactor 1: SPRE2 (Q7Z698)
Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)
Gene: SPRED2

Interactor 2: SPRE1 (Q7Z699)
Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
Gene: SPRED1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.44 1.00 0.665

The method score is based on:

Property Details
Experiments 32814053
Identification Methods two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains WH1~WH1
Common GO terms GO:0005173 - stem cell factor receptor binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0010719 - negative regulation of epithelial to mesenchymal transition
GO:0019901 - protein kinase binding
and 7 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 418
Hs

1 444
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Service provided by Combinatics, Japan

Last updated: 11Aug2025