Protein: SPY4
Protein sprouty homolog 4 (Spry-4)

Gene: SPY4, SPRY4
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q9C004

Gene Ontology (top 5):
GO:0004860 - protein kinase inhibitor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005925 - focal adhesion
GO:0032587 - ruffle membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

375918

RASK
GTPase KRas

3

10

High-throughput

0.640

High

1150285

TESK1
Dual specificity testis-specific protein kinase 1

2

6

Small-scale

0.631

High

1086993

PO4F2
POU domain, class 4, transcription factor 2

2

2

High-throughput

0.606

High

1123101

FHL2
Four and a half LIM domains protein 2

2

5

High-throughput

0.606

High

1180820

KLH38
Kelch-like protein 38

2

2

High-throughput

0.606

High

1235782

KR511
Keratin-associated protein 5-11

2

20

High-throughput

0.606

High

401446

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

4

Small-scale

0.601

High

1006170

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

2

0

High-throughput

0.595

High

651430

CBL
E3 ubiquitin-protein ligase CBL

1

7

Small-scale

0.589

High

221183

SPY2
Protein sprouty homolog 2

2

15

Small-scale

0.584

High

374179

RASN
GTPase NRas

2

10

High-throughput

0.584

High

374907

RASH
GTPase HRas

2

8

High-throughput

0.584

High

540661

LAMP1
Lysosome-associated membrane glycoprotein 1

2

3

High-throughput

0.584

High

976542

RB11A
Ras-related protein Rab-11A

2

3

High-throughput

0.584

High

965582

NTF2
Nuclear transport factor 2

2

0

High-throughput

0.580

High

1224901

TENS2
Tensin-2

2

1

High-throughput

0.576

High

1347862

RIN3
Ras and Rab interactor 3

2

1

High-throughput

0.576

High

209912

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

2

1

High-throughput

0.553

High

330305

VENTX
Homeobox protein VENTX

2

11

High-throughput

0.553

High

351601

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

5

High-throughput

0.553

High

733219

OTX1
Homeobox protein OTX1

2

3

High-throughput

0.553

High

885408

HXA1
Homeobox protein Hox-A1

2

16

High-throughput

0.553

High

1039818

CREB5
Cyclic AMP-responsive element-binding protein 5

2

4

High-throughput

0.553

High

562379

LAMP2
Lysosome-associated membrane glycoprotein 2

2

3

High-throughput

0.549

High

291862

STK16
Serine/threonine-protein kinase 16

1

4

High-throughput

0.536

High

630960

RAB4A
Ras-related protein Rab-4A

2

4

High-throughput

0.533

High

1307631

ZDH17
Palmitoyltransferase ZDHHC17

1

10

High-throughput

0.532

High

242845

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.515

High

246128

KIF1B
Kinesin-like protein KIF1B

1

4

High-throughput

0.515

High

384539

CRYAA
Alpha-crystallin A chain

1

2

High-throughput

0.515

High

415846

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.515

High

442464

GELS
Gelsolin

1

1

High-throughput

0.515

High

456271

CATD
Cathepsin D

1

2

High-throughput

0.515

High

702496

CLAT
Choline O-acetyltransferase

1

2

High-throughput

0.515

High

954606

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.515

High

981684

RAN
GTP-binding nuclear protein Ran

1

5

High-throughput

0.515

High

1279734

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

14

High-throughput

0.515

High

1369694

KLK6
Kallikrein-6

1

1

High-throughput

0.515

High

1420454

UBQL1
Ubiquilin-1

1

1

High-throughput

0.515

High

349557

TSN15
Tetraspanin-15

1

0

High-throughput

0.513

High

1390603

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1420457

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

731594

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.493

High

937105

CASP6
Caspase-6

1

0

High-throughput

0.493

High

1307553

ZDH13
Palmitoyltransferase ZDHHC13

1

10

High-throughput

0.489

High

226192

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

604188

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

630624

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.479

High

631455

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.479

High

693081

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

715758

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

845790

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

902050

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.479

High

953655

RAC3
Ras-related C3 botulinum toxin substrate 3

1

7

High-throughput

0.479

High

955560

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

956474

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.479

High

962450

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

978280

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.479

High

987922

GRB2
Growth factor receptor-bound protein 2

1

15

Small-scale

0.479

High

988682

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

1004189

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.479

High

1015753

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

1041262

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1145097

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.479

High

1151859

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.479

High

1159534

NTRK2
BDNF/NT-3 growth factors receptor

1

7

High-throughput

0.479

High

1270982

RHOU
Rho-related GTP-binding protein RhoU

1

10

High-throughput

0.479

High

47412

A0A6Q8PF08
Peripheral myelin protein 22

1

2

High-throughput

0.470

High

109506

G5E9A7
DM1 locus, WD repeat containing

1

3

High-throughput

0.470

High

280813

PR40A
Pre-mRNA-processing factor 40 homolog A

1

1

High-throughput

0.470

High

301681

WFS1
Wolframin

1

2

High-throughput

0.470

High

650396

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.470

High

705543

GRN
Progranulin

1

4

High-throughput

0.470

High

1289888

Q86V38
Atrophin 1

1

1

High-throughput

0.470

High

1420456

RNF11
RING finger protein 11

1

1

High-throughput

0.470

High

176540

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

390751

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

975224

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

989108

AP2B1
AP-2 complex subunit beta

1

0

High-throughput

0.458

High

1420451

ANFY1
Rabankyrin-5

1

0

High-throughput

0.458

High

1119295

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

180040

BET1
BET1 homolog

1

1

High-throughput

0.437

High

189815

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

218739

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

601434

RHOQ
Rho-related GTP-binding protein RhoQ

1

9

High-throughput

0.437

High

901022

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.437

High

945089

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.437

High

1233465

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1235325

STYK1
Tyrosine-protein kinase STYK1

1

6

High-throughput

0.437

High

1322973

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1420448

RHOJ
Rho-related GTP-binding protein RhoJ

1

9

High-throughput

0.437

High

1420453

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.437

High

1420455

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.437

High

839621

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.426

High

1322834

ORML3
ORM1-like protein 3

2

0

High-throughput

0.319

High

694394

CO8A1
Collagen alpha-1(VIII) chain

2

0

High-throughput

0.316

High

455935

ASGR1
Asialoglycoprotein receptor 1

1

0

High-throughput

0.279

Low

1420450

MYOF
Myoferlin

1

0

High-throughput

0.279

Low

389883

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

441564

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

1341311

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.268

Low

139978

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

327435

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

880676

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

1163414

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1293136

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1381954

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1420449

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1420452

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

255201

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

1357795

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025