HitPredict

Interactor 1: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Interactor 2: LITAF (Q99732)
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor) (Small integral membrane protein of lysosome/late endosome) (p53-induced gene 7 protein)
Gene: LITAF

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	25963657, 21326863
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 903 Hs			1 161
+	Hs
		1306061 WWP1_HUMAN (1-903): 0: 832: 57.54		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		125672 WWP2_HUMAN (1-903): 0: 816: 54.08		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		1299608 NED4L_HUMAN (5-900): 0: 762: 32.14		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		808241 NEDD4_HUMAN (90-900): 0: 673: 34.16		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Hs
		808268 NEDD4_HUMAN (90-900): 0: 673: 34.16		CDIP1_HUMAN (72-161): 2.31e-23: 93: 36.67
+	Mm
		808379 NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38		LITAF_MOUSE (1-161): 7.43e-50: 159: 85.71
+	Hs
		1306072 HECW2_HUMAN (1-512): 1.38e-13: 77.2: 11.34		LITAF_HUMAN (1-161): 1.08e-47: 153: 100.00
+	Ce
		1276020 WWP1_CAEEL (9-397): 4.21e-28: 123: 20.68		Q94184_CAEEL (67-161): 9.08e-21: 84.9: 33.68