HitPredict

Interactor 1: WASF2 (Q8BH43)
Actin-binding protein WASF2 (Protein WAVE-2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2)
Gene: WASF2

Interactor 2: ABI1 (Q8CBW3)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Ablphilin-1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	20697350, 18044991
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton GO:0017124 - SH3 domain binding GO:0030027 - lamellipodium GO:0031209 - SCAR complex GO:0035855 - megakaryocyte development and 1 others more... GO:0072673 - lamellipodium morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 497 Mm			1 481
+	Hs
		1316732 WASF2_HUMAN (1-497): 3.2e-81: 262: 85.60		ABI1_HUMAN (1-481): 1.06e-109: 336: 93.11
+	Hs
		1316724 WASF3_HUMAN (1-497): 2.57e-73: 242: 46.72		ABI1_HUMAN (1-481): 1.06e-109: 336: 93.11
+	Rn
		1203409 WASF1_RAT (1-495): 6.51e-60: 208: 41.94		ABI1_RAT (1-481): 6.1e-114: 346: 98.55
+	Hs
		1316686 WASF1_HUMAN (1-495): 1.06e-62: 215: 41.76		ABI1_HUMAN (1-481): 1.06e-109: 336: 93.11
+	Hs
		1452538 WASF2_HUMAN (1-497): 3.2e-81: 262: 85.60		ABI2_HUMAN (1-481): 1.74e-72: 240: 61.79
+	Hs
		1452526 WASF3_HUMAN (1-497): 2.57e-73: 242: 46.72		ABI2_HUMAN (1-481): 1.74e-72: 240: 61.79
+	Hs
		1364464 WASF1_HUMAN (1-495): 1.06e-62: 215: 41.76		ABI2_HUMAN (1-481): 1.74e-72: 240: 61.79
+	Dm
		99179 F2FB81_DROME (1-384): 5.02e-61: 213: 27.42		Q9Y0S9_DROME (1-477): 4.8e-70: 232: 35.98
+	Hs
		1124774 WASF2_HUMAN (1-497): 3.2e-81: 262: 85.60		SRC8_HUMAN (263-475): 1.3e-33: 135: 21.27
+	Hs
		1454450 WASF2_HUMAN (1-497): 3.2e-81: 262: 85.60		ABI3_HUMAN (276-475): 4.6e-15: 78.3: 24.04
+	Dm
		99175 F2FB81_DROME (1-384): 5.02e-61: 213: 27.42		DBNL_DROME (198-476): 8.16e-31: 127: 16.29
+	Hs
		1453449 WASF2_HUMAN (1-497): 3.2e-81: 262: 85.60		ITSN2_HUMAN (340-480): 6.94e-13: 73.3: 18.88
+	Hs
		1454443 WASF3_HUMAN (1-497): 2.57e-73: 242: 46.72		ABI3_HUMAN (276-475): 4.6e-15: 78.3: 24.04
+	Hs
		1364468 WASF1_HUMAN (1-495): 1.06e-62: 215: 41.76		ABI3_HUMAN (276-475): 4.6e-15: 78.3: 24.04
+	Hs
		215908 SYNJ1_HUMAN (136-474): 1.6e-15: 82: 14.83		AMPH_HUMAN (3-476): 5.66e-41: 157: 12.28
+	Hs
		215920 SYNJ1_HUMAN (136-474): 1.6e-15: 82: 14.83		MYO1E_HUMAN (228-476): 2.1e-31: 130: 20.23
+	Hs
		571698 PCLO_HUMAN (161-489): 1.11e-13: 76.2: 11.61		HCLS1_HUMAN (200-476): 3.06e-28: 119: 17.56
+	Mm
		1455913 PCLO_MOUSE (144-464): 3.43e-11: 68.1: 12.39		PCLO_MOUSE (102-409): 3.42e-18: 90.5: 14.15
+	Hs
		215925 SYNJ1_HUMAN (136-474): 1.6e-15: 82: 14.83		ITSN1_HUMAN (328-480): 3.11e-11: 68.3: 12.65
+	Hs
		215927 SYNJ1_HUMAN (136-474): 1.6e-15: 82: 14.83		SH319_HUMAN (408-476): 5.65e-09: 60.6: 34.78