Protein: CSN2
COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)

Gene: CSN2, COPS2
Organism: Homo sapiens
Interactions: 165
UniProt ID: P61201

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000338 - protein deneddylation
GO:0001833 - inner cell mass cell proliferation
GO:0001834 - trophectodermal cell proliferation
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

897288

CSN5
COP9 signalosome complex subunit 5

17

20

Small-scale

0.986

High

897331

CSN3
COP9 signalosome complex subunit 3

16

18

Small-scale

0.985

High

897237

CSN1
COP9 signalosome complex subunit 1

14

17

Small-scale

0.982

High

897267

CSN6
COP9 signalosome complex subunit 6

11

20

Small-scale

0.978

High

897302

CSN4
COP9 signalosome complex subunit 4

10

20

Small-scale

0.972

High

897300

CSN8
COP9 signalosome complex subunit 8

9

7

Small-scale

0.970

High

897324

CSN7A
COP9 signalosome complex subunit 7a

8

20

Small-scale

0.968

High

897312

CSN7B
COP9 signalosome complex subunit 7b

7

20

Small-scale

0.962

High

121722

PSD11
26S proteasome non-ATPase regulatory subunit 11

2

19

High-throughput

0.783

High

897245

CUL4A
Cullin-4A

13

20

Small-scale

0.762

High

897244

CUL3
Cullin-3

10

20

Small-scale

0.756

High

897243

CUL2
Cullin-2

9

20

Small-scale

0.755

High

897246

CUL4B
Cullin-4B

8

20

Small-scale

0.755

High

897242

CUL1
Cullin-1

7

20

Small-scale

0.749

High

897282

DDB2
DNA damage-binding protein 2

6

9

Small-scale

0.730

High

897277

DCA11
DDB1- and CUL4-associated factor 11

4

5

High-throughput

0.694

High

897294

LLR1
Leucine-rich repeat protein 1

4

3

High-throughput

0.694

High

897256

DDB1
DNA damage-binding protein 1

4

4

Small-scale

0.689

High

897289

CUL5
Cullin-5

3

20

Small-scale

0.674

High

895985

UBC12
NEDD8-conjugating enzyme Ubc12

3

5

High-throughput

0.667

High

897278

DCAF4
DDB1- and CUL4-associated factor 4

3

5

High-throughput

0.667

High

897285

APBP2
Amyloid protein-binding protein 2

3

5

High-throughput

0.667

High

897290

FBX17
F-box only protein 17

3

5

High-throughput

0.667

High

897301

KLDC3
Kelch domain-containing protein 3

3

15

High-throughput

0.667

High

897304

BTBD2
BTB/POZ domain-containing protein 2

3

20

High-throughput

0.667

High

897308

BTBD1
BTB/POZ domain-containing protein 1

3

20

High-throughput

0.667

High

897328

FEM1B
Protein fem-1 homolog B

3

3

High-throughput

0.667

High

897332

FBX7
F-box only protein 7

3

2

High-throughput

0.667

High

897314

FBX6
F-box only protein 6

3

5

High-throughput

0.656

High

897232

IRF8
Interferon regulatory factor 8

2

5

Small-scale

0.649

High

897224

CSN2
COP9 signalosome complex subunit 2

1

19

Small-scale

0.647

High

897238

ERCC8
DNA excision repair protein ERCC-8

3

9

Small-scale

0.640

High

50422

SYCE3
Synaptonemal complex central element protein 3

2

1

High-throughput

0.628

High

319409

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

3

High-throughput

0.628

High

897240

SKP2
S-phase kinase-associated protein 2

2

3

High-throughput

0.628

High

897253

STK11
Serine/threonine-protein kinase STK11

2

4

High-throughput

0.628

High

897262

KLH10
Kelch-like protein 10

2

17

High-throughput

0.628

High

897268

DET1
DET1 homolog

2

2

High-throughput

0.628

High

897271

FXL14
F-box/LRR-repeat protein 14

2

3

High-throughput

0.628

High

888329

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

Small-scale

0.618

High

500406

THA
Thyroid hormone receptor alpha

2

6

Small-scale

0.614

High

897231

PRAME
Melanoma antigen preferentially expressed in tumors

2

1

High-throughput

0.611

High

897254

NEDD8
NEDD8

2

7

Small-scale

0.611

High

897259

DCAF6
DDB1- and CUL4-associated factor 6

2

11

High-throughput

0.611

High

897280

CSN9
COP9 signalosome complex subunit 9

2

2

Small-scale

0.611

High

897333

DCAF1
DDB1- and CUL4-associated factor 1

2

5

Small-scale

0.611

High

897297

SIN3A
Paired amphipathic helix protein Sin3a

2

1

Small-scale

0.606

High

897329

FBXL5
F-box/LRR-repeat protein 5

2

0

High-throughput

0.602

High

897229

CSK21
Casein kinase II subunit alpha

2

8

Small-scale

0.595

High

897322

KLH13
Kelch-like protein 13

2

17

High-throughput

0.588

High

897234

EP300
Histone acetyltransferase p300

1

7

Small-scale

0.586

High

897315

ZN446
Zinc finger protein 446

2

0

High-throughput

0.580

High

207718

DENR
Density-regulated protein

2

1

High-throughput

0.574

High

487285

ANDR
Androgen receptor

1

8

Small-scale

0.573

High

876737

NP1L1
Nucleosome assembly protein 1-like 1

1

1

Small-scale

0.573

High

401743

JUN
Transcription factor Jun

2

9

Small-scale

0.571

High

897295

SENP8
Sentrin-specific protease 8

1

1

Small-scale

0.561

High

897309

ING2
Inhibitor of growth protein 2

1

1

Small-scale

0.561

High

897327

ING1
Inhibitor of growth protein 1

1

1

Small-scale

0.561

High

897307

NIF3L
NIF3-like protein 1

1

0

Small-scale

0.549

High

359819

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.536

High

586652

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.536

High

897251

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

3

High-throughput

0.536

High

897264

KLH24
Kelch-like protein 24

1

17

High-throughput

0.536

High

897270

FBX11
F-box only protein 11

1

1

High-throughput

0.536

High

897272

WDTC1
WD and tetratricopeptide repeats protein 1

1

11

High-throughput

0.536

High

897291

DCNL1
DCN1-like protein 1

1

2

High-throughput

0.536

High

897317

ASB6
Ankyrin repeat and SOCS box protein 6

1

3

High-throughput

0.536

High

897321

KLHL8
Kelch-like protein 8

1

17

High-throughput

0.536

High

878584

ALR
FAD-linked sulfhydryl oxidase ALR

1

1

Small-scale

0.534

High

897287

CBP
CREB-binding protein

1

7

Small-scale

0.534

High

897274

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

2

5

Small-scale

0.533

High

509929

VDR
Vitamin D3 receptor

1

8

Small-scale

0.527

High

850853

NR0B1
Nuclear receptor subfamily 0 group B member 1

1

3

Small-scale

0.527

High

897233

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

0

Small-scale

0.526

High

146615

SOCS2
Suppressor of cytokine signaling 2

1

2

High-throughput

0.515

High

639712

IKBA
NF-kappa-B inhibitor alpha

1

2

Small-scale

0.515

High

897323

WRP73
WD repeat-containing protein WRAP73

1

4

High-throughput

0.515

High

813299

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

897316

PLAT2
Phospholipase A and acyltransferase 2

1

0

High-throughput

0.513

High

174766

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.501

High

257761

SIN3B
Paired amphipathic helix protein Sin3b

1

1

Small-scale

0.501

High

475555

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.501

High

490093

COT1
COUP transcription factor 1

1

2

Small-scale

0.501

High

897230

H31
Histone H3.1

1

1

Small-scale

0.501

High

897249

KPCD1
Serine/threonine-protein kinase D1

1

2

Small-scale

0.501

High

897283

IP6K1
Inositol hexakisphosphate kinase 1

1

1

Small-scale

0.501

High

897296

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.493

High

281589

WFS1
Wolframin

1

0

High-throughput

0.493

High

835158

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.493

High

49982

PXDNL
Probable oxidoreductase PXDNL

1

1

High-throughput

0.489

High

299512

KLH18
Kelch-like protein 18

1

17

High-throughput

0.489

High

897258

ANR39
Ankyrin repeat domain-containing protein 39

1

5

High-throughput

0.489

High

897273

SYT2
Synaptotagmin-2

1

1

High-throughput

0.489

High

500474

THB
Thyroid hormone receptor beta

1

6

Small-scale

0.481

High

897286

RND1
Rho-related GTP-binding protein Rho6

1

5

Small-scale

0.481

High

261456

NCOR1
Nuclear receptor corepressor 1

1

0

Small-scale

0.480

High

897227

H4
Histone H4

1

0

Small-scale

0.480

High

129730

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

227037

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.479

High

242835

TRI13
E3 ubiquitin-protein ligase TRIM13

1

6

High-throughput

0.479

High

244200

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

262414

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

294611

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

386419

P53
Cellular tumor antigen p53

1

3

Small-scale

0.479

High

418098

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

552394

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

572913

PRS6A
26S proteasome regulatory subunit 6A

1

20

Small-scale

0.479

High

650842

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

714502

GRK5
G protein-coupled receptor kinase 5

1

3

High-throughput

0.479

High

720126

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

779140

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

885029

FBXW4
F-box/WD repeat-containing protein 4

1

7

Small-scale

0.479

High

893638

PSA6
Proteasome subunit alpha type-6

1

20

Small-scale

0.479

High

897225

PRS4
26S proteasome regulatory subunit 4

1

20

Small-scale

0.479

High

897226

PRS8
26S proteasome regulatory subunit 8

1

20

Small-scale

0.479

High

897228

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

High-throughput

0.479

High

897235

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

4

Small-scale

0.479

High

897236

CDC16
Cell division cycle protein 16 homolog

1

6

Small-scale

0.479

High

897239

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

897241

IRF5
Interferon regulatory factor 5

1

5

Small-scale

0.479

High

897248

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

5

High-throughput

0.479

High

897250

ELOB
Elongin-B

1

2

High-throughput

0.479

High

897252

TRIPB
Thyroid receptor-interacting protein 11

1

1

Small-scale

0.479

High

897255

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

3

Small-scale

0.479

High

897260

DCAF8
DDB1- and CUL4-associated factor 8

1

12

High-throughput

0.479

High

897261

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

897266

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

897269

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

897275

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

897276

COP1
E3 ubiquitin-protein ligase COP1

1

10

High-throughput

0.479

High

897279

PHIP
PH-interacting protein

1

5

Small-scale

0.479

High

897284

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.479

High

897298

CRBN
Protein cereblon

1

2

Small-scale

0.479

High

897303

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.479

High

897306

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

7

High-throughput

0.479

High

897311

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

897318

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

897319

DTL
Denticleless protein homolog

1

6

Small-scale

0.479

High

897320

IBTK
Inhibitor of Bruton tyrosine kinase

1

5

Small-scale

0.479

High

897325

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

897326

APC4
Anaphase-promoting complex subunit 4

1

1

Small-scale

0.479

High

897330

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

Small-scale

0.479

High

897334

MAFB
Transcription factor MafB

1

11

High-throughput

0.479

High

584578

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

Small-scale

0.458

High

641178

DNMT1
DNA

1

0

Small-scale

0.458

High

897247

TF2H2
General transcription factor IIH subunit 2

1

0

Small-scale

0.458

High

897310

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.458

High

897313

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.458

High

897299

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.457

High

120878

APBB1
Amyloid beta precursor protein binding family B member 1

1

3

High-throughput

0.445

High

496706

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

897257

KLH12
Kelch-like protein 12

1

17

High-throughput

0.445

High

122261

RN103
E3 ubiquitin-protein ligase RNF103

1

4

High-throughput

0.437

High

297598

RHBT1
Rho-related BTB domain-containing protein 1

1

14

High-throughput

0.437

High

897263

FBX42
F-box only protein 42

1

9

High-throughput

0.437

High

897305

RHBT2
Rho-related BTB domain-containing protein 2

1

14

High-throughput

0.437

High

315246

ABCA1
Phospholipid-transporting ATPase ABCA1

2

0

Small-scale

0.305

High

844462

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.279

Low

897281

RB40A
Ras-related protein Rab-40A

1

0

High-throughput

0.279

Low

897265

SOSD1
Sclerostin domain-containing protein 1

1

0

Small-scale

0.249

Low

897292

RN170
E3 ubiquitin-protein ligase RNF170

1

0

High-throughput

0.249

Low

483682

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

897293

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024