HitPredict

Interactor 1: WASF1 (Q92558)
Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)
Gene: WASF1

Interactor 2: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.647

Property	Details
Experiments	32296183, unassigned1304, unassigned3799
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030027 - lamellipodium GO:0030036 - actin cytoskeleton organization GO:0031209 - SCAR complex GO:0098885 - modification of postsynaptic actin cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 559 Hs			1 366
+	Mm
		1296529 WASF2_MOUSE (1-374): 2.99e-111: 342: 46.19		ABI1_MOUSE (1-314): 3.09e-64: 213: 34.35
+	Rn
		1203409 WASF1_RAT (1-559): 9.93e-69: 233: 97.50		ABI1_RAT (1-314): 1.01e-66: 219: 34.88
+	Hs
		1454443 WASF3_HUMAN (1-557): 6.8e-44: 164: 45.99		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		1454450 WASF2_HUMAN (1-541): 1.82e-39: 152: 42.33		ABI3_HUMAN (1-366): 5.41e-88: 271: 100.00
+	Hs
		1364464 WASF1_HUMAN (1-559): 2.43e-72: 243: 100.00		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		1316686 WASF1_HUMAN (1-559): 2.43e-72: 243: 100.00		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		987807 WASF1_HUMAN (1-559): 2.43e-72: 243: 100.00		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30
+	Hs
		1124774 WASF2_HUMAN (1-541): 1.82e-39: 152: 42.33		SRC8_HUMAN (40-363): 4.99e-43: 158: 16.12
+	Dm
		99175 F2FB81_DROME (1-250): 9.81e-41: 158: 42.46		DBNL_DROME (17-363): 3.49e-33: 131: 15.05
+	Hs
		1452526 WASF3_HUMAN (1-557): 6.8e-44: 164: 45.99		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		1452538 WASF2_HUMAN (1-541): 1.82e-39: 152: 42.33		ABI2_HUMAN (109-363): 1.97e-25: 108: 23.18
+	Hs
		1316724 WASF3_HUMAN (1-557): 6.8e-44: 164: 45.99		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Mm
		92772 D3Z656_MOUSE (123-535): 4.09e-36: 146: 13.52		SH3G2_MOUSE (265-363): 3.48e-27: 111: 24.75
+	Dd
		1200684 SCAR_DICDI (24-357): 1.74e-34: 137: 20.54		ABIA_DICDI (3-321): 7.75e-30: 119: 19.32
+	Dm
		99179 F2FB81_DROME (1-250): 9.81e-41: 158: 42.46		Q9Y0S9_DROME (260-364): 6.86e-21: 95.5: 38.32
+	Rn
		204410 SYNJ1_RAT (123-553): 2.32e-35: 144: 12.53		SH3G2_RAT (265-363): 2.51e-26: 109: 23.76
+	Hs
		1316732 WASF2_HUMAN (1-541): 1.82e-39: 152: 42.33		ABI1_HUMAN (124-363): 6.4e-21: 95.9: 24.49
+	Hs
		1453449 WASF2_HUMAN (1-541): 1.82e-39: 152: 42.33		ITSN2_HUMAN (306-365): 5.4e-13: 72.7: 37.50
+	Hs
		176259 SYNJ2_HUMAN (46-507): 1.46e-30: 129: 14.71		GRB2_HUMAN (312-363): 4.05e-14: 72.7: 28.30
+	Hs
		176266 SYNJ2_HUMAN (46-507): 1.46e-30: 129: 14.71		ITSN1_HUMAN (205-363): 5.28e-10: 63.2: 15.85