Protein: HCLS1
Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)

Gene: HCLS1
Organism: Homo sapiens
Interactions: 63
UniProt ID: P14317

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005667 - transcription regulator complex
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571692

SH24A
SH2 domain-containing protein 4A

5

20

High-throughput

0.932

High

463307

LYN
Tyrosine-protein kinase Lyn

2

20

Small-scale

0.789

High

571669

3BP2
SH3 domain-binding protein 2

2

20

High-throughput

0.783

High

571660

NOTC1
Neurogenic locus notch homolog protein 1

1

9

High-throughput

0.691

High

486656

FGR
Tyrosine-protein kinase Fgr

1

20

Small-scale

0.647

High

571667

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.647

High

571656

SYUA
Alpha-synuclein

2

4

High-throughput

0.628

High

571670

SNX1
Sorting nexin-1

2

10

High-throughput

0.628

High

571696

SNX5
Sorting nexin-5

2

9

High-throughput

0.628

High

571658

CASP3
Caspase-3

2

5

Small-scale

0.602

High

571661

TERF1
Telomeric repeat-binding factor 1

1

3

High-throughput

0.573

High

571676

A16L1
Autophagy-related protein 16-1

2

13

High-throughput

0.571

High

571698

PCLO
Protein piccolo

1

4

High-throughput

0.553

High

571653

ZBT25
Zinc finger and BTB domain-containing protein 25

1

11

High-throughput

0.541

High

571671

TRI29
Tripartite motif-containing protein 29

1

7

High-throughput

0.541

High

571686

QKI
KH domain-containing RNA-binding protein QKI

1

7

High-throughput

0.541

High

571690

SSBP3
Single-stranded DNA-binding protein 3

1

5

High-throughput

0.541

High

571691

GO45
Golgin-45

1

1

High-throughput

0.541

High

571697

NEMO
NF-kappa-B essential modulator

1

17

High-throughput

0.541

High

571650

EGLN
Endoglin

1

1

High-throughput

0.536

High

571689

KCNS3
Delayed-rectifier potassium channel regulatory subunit KCNS3

1

7

High-throughput

0.536

High

571693

SNX6
Sorting nexin-6

1

9

High-throughput

0.536

High

219545

WIPF1
WAS/WASL-interacting protein family member 1

1

20

Small-scale

0.515

High

571647

INGR1
Interferon gamma receptor 1

1

0

High-throughput

0.513

High

160988

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

19

Small-scale

0.501

High

384360

CRYAA
Alpha-crystallin A chain

1

2

High-throughput

0.501

High

571665

ARP3
Actin-related protein 3

1

20

Small-scale

0.501

High

571668

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

571680

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

4

High-throughput

0.494

High

256757

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

418812

H2A1B
Histone H2A type 1-B/E

1

10

High-throughput

0.479

High

449672

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.479

High

549729

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

1

Small-scale

0.479

High

571648

H2AX
Histone H2AX

1

10

High-throughput

0.479

High

571649

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

571651

H2A1D
Histone H2A type 1-D

1

10

High-throughput

0.479

High

571652

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.479

High

571654

U2AF2
Splicing factor U2AF 65 kDa subunit

1

5

High-throughput

0.479

High

571655

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

571659

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.479

High

571662

H2BFS
Histone H2B type F-S

1

20

High-throughput

0.479

High

571664

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

571666

CH10
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

571672

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.479

High

571673

H2B2F
Histone H2B type 2-F

1

20

High-throughput

0.479

High

571678

H2A3
Histone H2A type 3

1

10

High-throughput

0.479

High

571679

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.479

High

571682

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.479

High

571683

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

20

Small-scale

0.479

High

571684

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.479

High

571687

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.479

High

571688

H2B1L
Histone H2B type 1-L

1

20

High-throughput

0.479

High

571695

TRRAP
Transformation/transcription domain-associated protein

1

4

High-throughput

0.479

High

542314

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.458

High

571674

TEX35
Testis-expressed protein 35

1

0

High-throughput

0.458

High

563114

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.445

High

571657

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

5

High-throughput

0.445

High

571681

ZN283
Zinc finger protein 283

1

2

High-throughput

0.445

High

571663

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

8

High-throughput

0.437

High

571675

DCA15
DDB1- and CUL4-associated factor 15

1

5

High-throughput

0.437

High

571677

ZN474
Zinc finger protein 474

1

1

High-throughput

0.437

High

571694

TENN
Tenascin-N

1

6

High-throughput

0.437

High

571685

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025