HitPredict

Interactor 1: RYBP (Q8CCI5)
RING1 and YY1-binding protein (Death effector domain-associated factor) (DED-associated factor)
Gene: RYBP

Interactor 2: PCGF1 (Q8R023)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	22325148, 23395003
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0008270 - zinc ion binding GO:0031519 - PcG protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 228 Mm			1 259
+	Hs
		1326063 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		PCGF1_HUMAN (1-259): 2.87e-83: 251: 98.07
+	Hs
		765704 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		BMI1_HUMAN (30-255): 4.34e-67: 212: 35.87
+	Hs
		766103 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		PCGF2_HUMAN (30-255): 9.04e-62: 199: 36.40
+	Mm
		662907 RYBP_MOUSE (1-228): 4.85e-60: 190: 100.00		PCGF2_MOUSE (30-255): 2.18e-59: 193: 35.57
+	Hs
		765690 YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33		BMI1_HUMAN (30-255): 4.34e-67: 212: 35.87
+	Hs
		1185922 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		PCGF3_HUMAN (32-255): 1.37e-58: 188: 39.42
+	Hs
		766102 YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33		PCGF2_HUMAN (30-255): 9.04e-62: 199: 36.40
+	Hs
		1326075 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		PCGF6_HUMAN (26-252): 1.52e-48: 165: 35.50
+	Mm
		1298253 RYBP_MOUSE (1-228): 4.85e-60: 190: 100.00		PCGF6_MOUSE (26-252): 1.83e-46: 159: 34.63
+	Mm
		1298254 RYBP_MOUSE (1-228): 4.85e-60: 190: 100.00		RING2_MOUSE (24-259): 1.46e-45: 157: 15.34
+	Hs
		1326047 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		RING2_HUMAN (24-259): 1.92e-45: 156: 15.34
+	Hs
		1286245 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		PCGF5_HUMAN (30-255): 5.29e-45: 153: 28.85
+	Mm
		1408843 YAF2_MOUSE (3-227): 4.02e-57: 181: 54.67		RING2_MOUSE (24-259): 1.46e-45: 157: 15.34
+	Hs
		623443 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		RO52_HUMAN (32-220): 1.66e-37: 139: 20.31
+	Hs
		572069 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		TRI27_HUMAN (32-225): 1.36e-34: 131: 14.43
+	Mm
		205495 RYBP_MOUSE (1-228): 4.85e-60: 190: 100.00		RING1_MOUSE (24-153): 8.08e-34: 128: 21.64
+	Hs
		1055825 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		RING1_HUMAN (24-153): 5.4e-33: 125: 21.64
+	Hs
		1055823 YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33		RING1_HUMAN (24-153): 5.4e-33: 125: 21.64
+	Hs
		1089230 YAF2_HUMAN (3-227): 1.43e-52: 169: 53.33		TRI26_HUMAN (32-223): 5.67e-29: 116: 19.90
+	Hs
		302583 RYBP_HUMAN (1-228): 1.1e-59: 189: 99.12		RNF8_HUMAN (24-130): 4.06e-10: 61.3: 28.04