HitPredict

Interactor 1: DHB14 (Q9BPX1)
17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1)
Gene: HSD17B14

Interactor 2: DHB14 (Q9BPX1)
17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1)
Gene: HSD17B14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.952

The method score is based on:

Property Details
Experiments 25416956, 16189514, 27107012, 32296183, 31515488, unassigned1304
Identification Methods two hybrid, two hybrid array, barcode fusion genetics two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains adh_short_C2~adh_short_C2
Common GO terms GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005829 - cytosol
GO:0006706 - steroid catabolic process
GO:0047045 - testosterone 17-beta-dehydrogenase (NADP+) activity
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 270
Hs

1 270
+ Hs
+ Dm
+ Dm
+ Dm
+ Hs
+ Dm
+ Ce
+ Ss
+ At
+ At
+ Ce
+ At
+ At
+ At
+ At
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024