HitPredict

Interactor 1: EIF3F (O00303)
Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)
Gene: EIF3F

Interactor 2: EIF3M (Q7L2H7)
Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1)
Gene: EIF3M

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 17403899, 32296183, 24981860, 31839598, 26186194, 28514442, 16169070, 31527668, 33961781, 40437099, 19615732, 18599441, 23623729, 25416956, unassigned1304, unassigned3799
Identification Methods affinity chromatography technology, two hybrid, cross-linking study, mass spectrometry studies of complexes, anti tag coimmunoprecipitation, pull down, bimolecular fluorescence complementation, two hybrid array, two hybrid prey pooling approach, mammalian protein protein interaction trap and 2 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains MitMem_reg~eIF3m_C_helix, MitMem_reg~PCI
Common GO terms GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005852 - eukaryotic translation initiation factor 3 complex
GO:0006413 - translational initiation
and 4 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 357
Hs

1 374
+ Hs
+ Dm
+ Dm
+ Hs
+ Hs
+ Dm
+ Ce
+ Ce
+ Sp
+ Mm
+ Hs
+ Sp
+ Hs
+ Hs
+ Hs
+ Dm
+ Sc
+ Dm
+ At
+ At

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Last updated: 11Aug2025