Protein: EIF3M
Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1)

Gene: EIF3M
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q7L2H7

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0002183 - cytoplasmic translational initiation
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005852 - eukaryotic translation initiation factor 3 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

131456

EIF3F
Eukaryotic translation initiation factor 3 subunit F

16

20

Small-scale

0.986

High

187991

EIF3H
Eukaryotic translation initiation factor 3 subunit H

12

20

Small-scale

0.981

High

1121806

EIF3A
Eukaryotic translation initiation factor 3 subunit A

9

2

Small-scale

0.972

High

949383

EIF3E
Eukaryotic translation initiation factor 3 subunit E

7

4

Small-scale

0.964

High

1271683

EIF3K
Eukaryotic translation initiation factor 3 subunit K

7

1

Small-scale

0.964

High

1271693

EIF3L
Eukaryotic translation initiation factor 3 subunit L

7

1

Small-scale

0.964

High

1271667

EIF3C
Eukaryotic translation initiation factor 3 subunit C

6

3

Small-scale

0.944

High

81719

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

4

3

High-throughput

0.903

High

128262

PSD12
26S proteasome non-ATPase regulatory subunit 12

3

20

High-throughput

0.871

High

939364

EIF3B
Eukaryotic translation initiation factor 3 subunit B

7

3

Small-scale

0.747

High

295197

EIF3G
Eukaryotic translation initiation factor 3 subunit G

6

1

Small-scale

0.733

High

1102858

EIF3I
Eukaryotic translation initiation factor 3 subunit I

6

2

Small-scale

0.733

High

187742

EIF3D
Eukaryotic translation initiation factor 3 subunit D

7

0

Small-scale

0.713

High

1257906

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

3

2

High-throughput

0.667

High

1124268

IF4A2
Eukaryotic initiation factor 4A-II

3

1

High-throughput

0.650

High

342931

HERC2
E3 ubiquitin-protein ligase HERC2

3

4

Small-scale

0.633

High

953921

IF4A1
Eukaryotic initiation factor 4A-I

2

2

High-throughput

0.628

High

447152

NPM
Nucleophosmin

2

1

High-throughput

0.611

High

625458

CSK22
Casein kinase II subunit alpha'

2

6

High-throughput

0.611

High

997820

CSK21
Casein kinase II subunit alpha

2

7

High-throughput

0.611

High

372398

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.585

High

1047035

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

2

1

Small-scale

0.584

High

1271678

ANLN
Anillin

2

1

High-throughput

0.584

High

396400

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

631308

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

295342

EIF3J
Eukaryotic translation initiation factor 3 subunit J

2

0

Small-scale

0.569

High

1271682

ABI3
ABI gene family member 3

2

1

High-throughput

0.553

High

1271665

SRPK1
SRSF protein kinase 1

1

3

High-throughput

0.550

High

249761

DOK2
Docking protein 2

2

0

High-throughput

0.547

High

415672

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

431171

LA
Lupus La protein

1

2

High-throughput

0.536

High

563972

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.536

High

765650

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

832068

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

1

High-throughput

0.536

High

884140

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

933330

IF5
Eukaryotic translation initiation factor 5

1

1

High-throughput

0.536

High

959194

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.536

High

992820

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.536

High

1052052

CALD1
Caldesmon

1

1

High-throughput

0.536

High

1152126

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

1271661

AURKB
Aurora kinase B

1

2

High-throughput

0.536

High

1271662

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.536

High

1271669

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.536

High

1271679

DDX21
Nucleolar RNA helicase 2

1

1

High-throughput

0.536

High

1271685

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.536

High

1271690

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

High-throughput

0.536

High

254626

EIF1B
Eukaryotic translation initiation factor 1b

1

2

High-throughput

0.515

High

303584

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

445568

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

479436

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

581553

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

0

High-throughput

0.513

High

785249

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

788694

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

859334

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

897045

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

969939

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

973484

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

985732

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

1016069

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1089727

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.513

High

1126452

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

1271638

GSTA5
Glutathione S-transferase A5

1

0

High-throughput

0.513

High

1271694

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

1271695

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.513

High

422417

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

1271642

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

2

Small-scale

0.501

High

484580

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

687259

HMGB2
High mobility group protein B2

1

2

High-throughput

0.489

High

775167

FUS
RNA-binding protein FUS

1

2

High-throughput

0.489

High

1065258

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.489

High

1271649

PSD4
PH and SEC7 domain-containing protein 4

1

2

High-throughput

0.489

High

1271668

RBM42
RNA-binding protein 42

1

1

High-throughput

0.489

High

1032187

EXOSX
Exosome complex component 10

1

0

High-throughput

0.486

High

132124

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

157541

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

216098

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

1

High-throughput

0.479

High

242099

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

375654

RASK
GTPase KRas

1

2

High-throughput

0.479

High

414092

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

537398

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

788948

TGFR2
TGF-beta receptor type-2

1

1

High-throughput

0.479

High

830964

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

867237

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

902278

RB27A
Ras-related protein Rab-27A

1

1

High-throughput

0.479

High

929981

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

970697

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1067460

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

1100858

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

1106976

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1109557

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

High-throughput

0.479

High

1122518

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

High-throughput

0.479

High

1134966

CUL7
Cullin-7

1

3

High-throughput

0.479

High

1138343

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1194175

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

1226941

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1229543

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

1271640

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1271643

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

1271645

DDX60
Probable ATP-dependent RNA helicase DDX60

1

1

High-throughput

0.479

High

1271648

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1271651

CSK23
Casein kinase II subunit alpha 3

1

7

High-throughput

0.479

High

1271654

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.479

High

1271660

OPTN
Optineurin

1

2

High-throughput

0.479

High

1271663

SNX27
Sorting nexin-27

1

4

High-throughput

0.479

High

1271674

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

1271677

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1271684

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1271686

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.479

High

1271688

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

1271689

UBQL1
Ubiquilin-1

1

11

High-throughput

0.479

High

1271698

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

1271699

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

363481

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

648185

NDKB
Nucleoside diphosphate kinase B

1

0

High-throughput

0.458

High

660657

IF4B
Eukaryotic translation initiation factor 4B

1

0

Small-scale

0.458

High

684284

DDX6
Probable ATP-dependent RNA helicase DDX6

1

0

High-throughput

0.458

High

767249

MERL
Merlin

1

0

High-throughput

0.458

High

957773

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

1026442

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1123953

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

1271641

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

1271644

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.458

High

1271658

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1271659

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1271666

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1271673

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

0

High-throughput

0.458

High

1271680

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1271691

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.458

High

1271696

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

1271697

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

401040

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.445

High

468533

HS90B
Heat shock protein HSP 90-beta

1

2

Small-scale

0.445

High

530010

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

567435

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.445

High

1209313

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1234841

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.445

High

260116

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.437

High

283498

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.437

High

315723

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.437

High

324949

HEXI1
Protein HEXIM1

1

1

High-throughput

0.437

High

377221

SOMA
Somatotropin

1

1

High-throughput

0.437

High

407106

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.437

High

412149

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

589004

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

695791

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

768504

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

799234

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.437

High

879218

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

1109585

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

1

High-throughput

0.437

High

1218975

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.437

High

1254373

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1271637

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

1271639

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1271655

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.437

High

1271656

ESR2
Estrogen receptor beta

1

6

High-throughput

0.437

High

1271657

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.437

High

1271672

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

1271676

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.437

High

1203173

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

430074

JUN
Transcription factor Jun

1

6

High-throughput

0.407

High

1271675

GPBL1
Vasculin-like protein 1

2

0

High-throughput

0.328

High

294630

ZMY10
Zinc finger MYND domain-containing protein 10

2

0

High-throughput

0.316

High

1252004

ZN783
Zinc finger protein 783

2

0

High-throughput

0.316

High

1271647

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

0

High-throughput

0.316

High

542560

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.279

Low

886520

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.279

Low

1126968

RBM39
RNA-binding protein 39

1

0

High-throughput

0.279

Low

1271653

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.279

Low

1271664

RBM14
RNA-binding protein 14

1

0

High-throughput

0.279

Low

1271687

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.279

Low

106167

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

869054

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.249

Low

965049

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

993080

KCNJ2
Inward rectifier potassium channel 2

1

0

Small-scale

0.249

Low

1085767

TF3C1
General transcription factor 3C polypeptide 1

1

0

High-throughput

0.249

Low

1136654

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.249

Low

1241667

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.249

Low

1271646

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.249

Low

1271650

FA13C
Protein FAM13C

1

0

High-throughput

0.249

Low

1271671

ARP6
Actin-related protein 6

1

0

High-throughput

0.249

Low

1271681

SYBU
Syntabulin

1

0

High-throughput

0.249

Low

1271692

SCN8A
Sodium channel protein type 8 subunit alpha

1

0

High-throughput

0.249

Low

516545

CALM3
Calmodulin-3

1

0

High-throughput

0.232

Low

635895

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.232

Low

1214153

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

1271652

TB22A
TBC1 domain family member 22A

1

0

Small-scale

0.232

Low

1271670

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025