Protein: CSN7A
COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)

Gene: CSN7A, COPS7A
Organism: Homo sapiens
Interactions: 147
UniProt ID: Q9UBW8

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1370434

CSN5
COP9 signalosome complex subunit 5

18

20

Small-scale

0.987

High

1272585

CSN6
COP9 signalosome complex subunit 6

14

20

Small-scale

0.983

High

1458847

CSN3
COP9 signalosome complex subunit 3

14

18

Small-scale

0.981

High

1406135

CSN8
COP9 signalosome complex subunit 8

10

4

Small-scale

0.972

High

958730

CSN2
COP9 signalosome complex subunit 2

9

20

Small-scale

0.970

High

1413213

CSN4
COP9 signalosome complex subunit 4

6

9

Small-scale

0.947

High

1094437

CSN1
COP9 signalosome complex subunit 1

5

20

Small-scale

0.919

High

1437202

CSN7B
COP9 signalosome complex subunit 7b

2

3

High-throughput

0.811

High

1114549

CUL3
Cullin-3

10

12

Small-scale

0.753

High

1363101

DDB2
DNA damage-binding protein 2

8

4

Small-scale

0.748

High

1115115

CUL4A
Cullin-4A

7

12

Small-scale

0.743

High

1115476

CUL4B
Cullin-4B

6

12

Small-scale

0.732

High

1352278

DCA11
DDB1- and CUL4-associated factor 11

5

2

High-throughput

0.718

High

1112762

CUL1
Cullin-1

5

12

Small-scale

0.712

High

1157980

DDB1
DNA damage-binding protein 1

4

1

Small-scale

0.686

High

1098383

ERCC8
DNA excision repair protein ERCC-8

4

3

Small-scale

0.676

High

1429764

BTBD1
BTB/POZ domain-containing protein 1

3

7

High-throughput

0.675

High

957542

UBC12
NEDD8-conjugating enzyme Ubc12

3

2

High-throughput

0.667

High

1113010

CUL2
Cullin-2

3

12

High-throughput

0.667

High

1272683

DET1
DET1 homolog

3

1

High-throughput

0.667

High

1357593

DCAF4
DDB1- and CUL4-associated factor 4

3

2

High-throughput

0.667

High

1371890

CUL5
Cullin-5

3

12

High-throughput

0.667

High

1235391

KLH10
Kelch-like protein 10

3

3

High-throughput

0.662

High

1458850

FBX7
F-box only protein 7

3

1

High-throughput

0.662

High

1458851

DCAF1
DDB1- and CUL4-associated factor 1

3

4

Small-scale

0.656

High

1156711

NF2L2
Nuclear factor erythroid 2-related factor 2

2

6

Small-scale

0.629

High

220719

DENR
Density-regulated protein

2

1

High-throughput

0.628

High

342410

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

1

High-throughput

0.628

High

501783

RB40L
Ras-related protein Rab-40A-like

2

2

High-throughput

0.628

High

1101920

SKP2
S-phase kinase-associated protein 2

2

4

High-throughput

0.628

High

1416612

BTBD2
BTB/POZ domain-containing protein 2

2

7

High-throughput

0.628

High

984005

RBX1
E3 ubiquitin-protein ligase RBX1

2

2

High-throughput

0.611

High

1154949

NEDD8
Ubiquitin-like protein NEDD8

2

3

Small-scale

0.611

High

1396702

LLR1
Leucine-rich repeat protein 1

2

1

High-throughput

0.611

High

1415896

DDA1
DET1- and DDB1-associated protein 1

2

1

High-throughput

0.611

High

318901

RHBT1
Rho-related BTB domain-containing protein 1

3

4

High-throughput

0.609

High

1323400

FXL14
F-box/LRR-repeat protein 14

2

0

High-throughput

0.602

High

1154467

STK11
Serine/threonine-protein kinase STK11

2

3

High-throughput

0.601

High

1458852

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

3

Small-scale

0.584

High

998089

CSK21
Casein kinase II subunit alpha

1

4

Small-scale

0.578

High

95848

E7EM64
COP9 signalosome complex subunit 6

1

20

High-throughput

0.575

High

96941

E9PGT6
COP9 signalosome subunit 8

1

3

High-throughput

0.575

High

1327612

WDTC1
WD and tetratricopeptide repeats protein 1

2

7

High-throughput

0.571

High

1143105

KPCD1
Serine/threonine-protein kinase D1

1

3

Small-scale

0.561

High

167987

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.552

High

770788

PGH2
Prostaglandin G/H synthase 2

1

0

Small-scale

0.537

High

50942

SYCE3
Synaptonemal complex central element protein 3

1

1

High-throughput

0.536

High

298632

RAD17
Cell cycle checkpoint protein RAD17

1

1

High-throughput

0.536

High

603692

JUNB
Transcription factor JunB

1

5

High-throughput

0.536

High

627727

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

1

High-throughput

0.536

High

884257

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

1150498

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

2

High-throughput

0.536

High

1208968

DCA10
DDB1- and CUL4-associated factor 10

1

1

High-throughput

0.536

High

1279483

KCD20
BTB/POZ domain-containing protein KCTD20

1

2

High-throughput

0.536

High

1335330

FA98A
Protein FAM98A

1

1

High-throughput

0.536

High

1360285

CSN9
COP9 signalosome complex subunit 9

1

1

High-throughput

0.536

High

1388933

FBX17
F-box only protein 17

1

3

High-throughput

0.536

High

1391969

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.536

High

1399403

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

1

High-throughput

0.536

High

1411034

COR1B
Coronin-1B

1

2

High-throughput

0.536

High

1450095

AP5S1
AP-5 complex subunit sigma-1

1

1

High-throughput

0.536

High

1451556

ASB6
Ankyrin repeat and SOCS box protein 6

1

1

High-throughput

0.536

High

1454746

KLH13
Kelch-like protein 13

1

5

High-throughput

0.536

High

1458853

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

1241975

FBX42
F-box only protein 42

2

2

High-throughput

0.533

High

290270

TM1L1
TOM1-like protein 1

1

0

High-throughput

0.518

High

190173

TNC18
Trinucleotide repeat-containing gene 18 protein

1

0

High-throughput

0.513

High

257281

PQBP1
Polyglutamine-binding protein 1

1

0

High-throughput

0.513

High

725561

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

0

High-throughput

0.513

High

1206917

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.513

High

1326766

CCD82
Coiled-coil domain-containing protein 82

1

0

High-throughput

0.513

High

1382435

ISL2
Insulin gene enhancer protein ISL-2

1

0

High-throughput

0.513

High

1390180

MCRS1
Microspherule protein 1

1

0

High-throughput

0.513

High

1419605

NUF2
Kinetochore protein Nuf2

1

0

High-throughput

0.513

High

1451548

PLAT2
Phospholipase A and acyltransferase 2

1

0

High-throughput

0.513

High

1458843

CDC23
Cell division cycle protein 23 homolog

1

0

High-throughput

0.513

High

1458845

FBXL5
F-box/LRR-repeat protein 5

1

0

High-throughput

0.513

High

1200341

ANR39
Ankyrin repeat domain-containing protein 39

1

2

High-throughput

0.489

High

1331871

SYT2
Synaptotagmin-2

1

1

High-throughput

0.489

High

401646

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

Small-scale

0.481

High

1279410

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

1

Small-scale

0.481

High

995328

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.480

High

316115

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

589943

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

696765

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

762064

GRK5
G protein-coupled receptor kinase 5

1

1

High-throughput

0.479

High

769418

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

872841

SOX2
Transcription factor SOX-2

1

1

Small-scale

0.479

High

935241

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

945599

FBXW4
F-box/WD repeat-containing protein 4

1

5

Small-scale

0.479

High

977400

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.479

High

986789

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

1060699

SOS1
Son of sevenless homolog 1

1

2

Small-scale

0.479

High

1147299

ELOB
Elongin-B

1

1

High-throughput

0.479

High

1152280

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

Small-scale

0.479

High

1202254

DCAF6
DDB1- and CUL4-associated factor 6

1

8

High-throughput

0.479

High

1205191

CT451
Cancer/testis antigen family 45 member A1

1

3

High-throughput

0.479

High

1229741

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

1255943

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1338414

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1340828

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

1359716

PHIP
PH-interacting protein

1

2

Small-scale

0.479

High

1368406

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.479

High

1403143

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

1412381

BTBDA
BTB/POZ domain-containing protein 10

1

2

High-throughput

0.479

High

1420895

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

High-throughput

0.479

High

1434137

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1445935

RAB18
Ras-related protein Rab-18

1

1

Small-scale

0.479

High

1448301

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

1453337

DTL
Denticleless protein homolog

1

4

High-throughput

0.479

High

1458842

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1458846

FBW1B
F-box/WD repeat-containing protein 11

1

3

High-throughput

0.479

High

1458848

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

1

Small-scale

0.479

High

1458849

FBW1A
F-box/WD repeat-containing protein 1A

1

3

Small-scale

0.479

High

1327245

FBXL6
F-box/LRR-repeat protein 6

1

4

High-throughput

0.470

High

1240786

PMF1
Polyamine-modulated factor 1

1

0

Small-scale

0.460

High

775478

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.458

High

1110889

IRF5
Interferon regulatory factor 5

1

0

Small-scale

0.458

High

1352900

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.458

High

1452007

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.458

High

1458844

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.458

High

85168

B7Z503
BTB

1

2

High-throughput

0.445

High

104040

F5GZ90
Denticleless protein homolog

1

4

High-throughput

0.445

High

430460

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

530510

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

1034538

TAGL
Transgelin

1

2

High-throughput

0.445

High

1199048

KLH12
Kelch-like protein 12

1

3

High-throughput

0.445

High

1199736

KLH22
Kelch-like protein 22

1

5

High-throughput

0.445

High

1215379

DCAF8
DDB1- and CUL4-associated factor 8

1

7

High-throughput

0.445

High

1340601

CT453
Cancer/testis antigen family 45 member A3

1

3

High-throughput

0.445

High

1397883

KLH15
Kelch-like protein 15

1

5

High-throughput

0.445

High

533792

CLUS
Clusterin

1

0

High-throughput

0.438

High

1448522

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1041346

CAV1
Caveolin-1

1

1

Small-scale

0.437

High

1419428

RHBT2
Rho-related BTB domain-containing protein 2

1

5

High-throughput

0.437

High

388324

GLPA
Glycophorin-A

1

0

High-throughput

0.426

High

1136956

ABRX2
BRISC complex subunit Abraxas 2

1

0

Small-scale

0.426

High

516135

CT456
Cancer/testis antigen family 45 member A6

1

3

High-throughput

0.407

High

458179

CASK
Kappa-casein

2

0

Small-scale

0.305

High

390346

CXCL7
Platelet basic protein

1

0

High-throughput

0.282

High

1219478

SLX4I
Protein SLX4IP

1

0

High-throughput

0.279

Low

1403465

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

437507

CASB
Beta-casein

1

0

Small-scale

0.249

Low

866452

CASA1
Alpha-S1-casein [Cleaved into: Casoxin-D]

1

0

Small-scale

0.249

Low

1433282

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

1104152

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1398008

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025