Protein: RPN9
26S proteasome regulatory subunit RPN9 (Proteasome non-ATPase subunit 7)

Gene: RPN9
Organism: Saccharomyces cerevisiae S288C
Interactions: 136
UniProt ID: Q04062

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005198 - structural molecule activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

850192

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

27

20

Small-scale

0.990

High

1044980

RPN5
26S proteasome regulatory subunit RPN5

16

20

Small-scale

0.985

High

806815

RPN10
26S proteasome regulatory subunit RPN10

11

6

Small-scale

0.978

High

1044981

RPN6
26S proteasome regulatory subunit RPN6

11

20

Small-scale

0.976

High

1044975

RPN8
26S proteasome regulatory subunit RPN8

9

20

Small-scale

0.974

High

738336

RPN12
26S proteasome regulatory subunit RPN12

7

3

Small-scale

0.962

High

1044969

RPN7
26S proteasome regulatory subunit RPN7

4

20

High-throughput

0.900

High

817088

RPN3
26S proteasome regulatory subunit RPN3

4

10

High-throughput

0.892

High

314908

SEM1
26S proteasome complex subunit SEM1

5

0

Small-scale

0.865

High

803679

RPN1
26S proteasome regulatory subunit RPN1

9

11

Small-scale

0.749

High

750775

PRS6A
26S proteasome regulatory subunit 6A

9

17

Small-scale

0.749

High

1033882

PRS8
26S proteasome regulatory subunit 8 homolog

6

16

Small-scale

0.730

High

751004

PRS7
26S proteasome regulatory subunit 7 homolog

6

14

Small-scale

0.729

High

744016

RAD23
UV excision repair protein RAD23

6

15

Small-scale

0.727

High

750893

PRS6B
26S proteasome regulatory subunit 6B homolog

5

13

Small-scale

0.722

High

893074

PSD10
Probable 26S proteasome regulatory subunit p28

5

1

Small-scale

0.716

High

850349

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

5

3

High-throughput

0.716

High

740222

RPN2
26S proteasome regulatory subunit RPN2

5

10

Small-scale

0.712

High

798572

HSM3
DNA mismatch repair protein HSM3

7

0

Small-scale

0.709

High

921102

PRS10
26S proteasome subunit RPT4

4

18

High-throughput

0.691

High

645202

PSB4
Proteasome subunit beta type-4

4

13

Small-scale

0.683

High

918106

RPN14
26S proteasome regulatory subunit RPN14

3

2

High-throughput

0.667

High

822433

PRS4
26S proteasome regulatory subunit 4 homolog

3

15

High-throughput

0.662

High

803167

ECM29
Proteasome component ECM29

3

1

High-throughput

0.656

High

150308

RPN13
26S proteasome regulatory subunit RPN13

3

0

High-throughput

0.634

High

858355

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.631

High

1044966

RPN9
26S proteasome regulatory subunit RPN9

1

13

High-throughput

0.618

High

821988

PSA6
Proteasome subunit alpha type-6

2

11

High-throughput

0.611

High

822019

PSA4
Proteasome subunit alpha type-4

2

12

High-throughput

0.611

High

616451

SEC18
Vesicular-fusion protein SEC18

2

3

High-throughput

0.601

High

873808

DSK2
Ubiquitin domain-containing protein DSK2

2

14

Small-scale

0.601

High

917059

MCM6
DNA replication licensing factor MCM6

2

1

High-throughput

0.588

High

636607

PSA7
Probable proteasome subunit alpha type-7

2

14

High-throughput

0.584

High

661559

PSA2
Proteasome subunit alpha type-2

2

10

High-throughput

0.584

High

671085

SIS1
Protein SIS1

2

1

High-throughput

0.584

High

561525

TBP
TATA-box-binding protein

2

0

High-throughput

0.563

High

527594

HSP72
Heat shock protein SSA2

2

3

High-throughput

0.552

High

546152

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.552

High

819705

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.552

High

802590

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

486515

TBA3
Tubulin alpha-3 chain

1

0

High-throughput

0.513

High

744507

KA122
Importin beta-like protein KAP122

1

0

High-throughput

0.513

High

918563

YG2A
Zinc finger protein YGR067C

1

2

Small-scale

0.508

High

509706

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

13

High-throughput

0.501

High

748196

SUI1
Eukaryotic translation initiation factor eIF-1

1

2

Small-scale

0.494

High

813394

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.493

High

844322

SPG5
Stationary phase protein 5

1

0

High-throughput

0.493

High

1044978

TIP41
Type 2A phosphatase activator TIP41

1

0

High-throughput

0.493

High

393275

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.479

High

580008

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

636684

PSA1
Proteasome subunit alpha type-1

1

11

High-throughput

0.479

High

661436

PSA3
Proteasome subunit alpha type-3

1

12

High-throughput

0.479

High

662056

PSB6
Proteasome subunit beta type-6

1

18

High-throughput

0.479

High

668407

PSB2
Proteasome subunit beta type-2

1

12

High-throughput

0.479

High

675261

PSB3
Proteasome subunit beta type-3

1

14

High-throughput

0.479

High

680032

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

721276

PSB5
Proteasome subunit beta type-5

1

16

High-throughput

0.479

High

721328

PSB7
Proteasome subunit beta type-7

1

17

High-throughput

0.479

High

727295

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

734198

EF2
Elongation factor 2

1

2

Small-scale

0.479

High

735957

PSA5
Proteasome subunit alpha type-5

1

11

High-throughput

0.479

High

747564

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

779964

DOA1
Protein DOA1

1

5

Small-scale

0.479

High

800859

PSB1
Proteasome subunit beta type-1

1

16

High-throughput

0.479

High

818426

DDI1
DNA damage-inducible protein 1

1

2

Small-scale

0.479

High

826322

PSMD9
Probable 26S proteasome regulatory subunit p27

1

1

Small-scale

0.479

High

849948

BLM10
Proteasome activator BLM10

1

1

High-throughput

0.479

High

917319

INO80
Chromatin-remodeling ATPase INO80

1

2

Small-scale

0.479

High

1038099

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.479

High

435340

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

503225

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

512635

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

513205

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

514823

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

603103

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

647209

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

708085

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

737941

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

753570

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

776645

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

780002

POC2
Proteasome assembly chaperone 2

1

0

High-throughput

0.458

High

797536

UMP1
Proteasome maturation factor UMP1

1

0

High-throughput

0.458

High

820807

CCS1
Superoxide dismutase 1 copper chaperone

1

0

High-throughput

0.458

High

826801

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

865327

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

871524

HGH1
Protein HGH1

1

0

Small-scale

0.458

High

874341

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.458

High

897499

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.458

High

924459

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.458

High

1033548

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

1044451

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

1044723

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1044968

POC1
Proteasome chaperone 1

1

0

High-throughput

0.458

High

1044970

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

1044971

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

1044979

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

525045

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

721415

MCM4
DNA replication licensing factor MCM4

1

1

High-throughput

0.445

High

742326

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

817945

IMB4
Importin subunit beta-4

1

1

High-throughput

0.445

High

858061

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.445

High

581902

SYKC
Lysine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.437

High

800819

RCK2
Serine/threonine-protein kinase RCK2

1

2

High-throughput

0.437

High

824786

MLP2
Protein MLP2

1

2

High-throughput

0.437

High

672030

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.426

High

865640

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.426

High

1028604

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.426

High

1030568

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.426

High

752690

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

801735

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.407

High

816384

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.407

High

925471

ARK1
Actin-regulating kinase 1

1

2

High-throughput

0.407

High

471431

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

2

0

High-throughput

0.328

High

1043564

ESC1
Silent chromatin protein ESC1

2

0

High-throughput

0.305

High

1044972

VAC14
Vacuole morphology and inheritance protein 14

1

0

Small-scale

0.282

High

639572

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.279

Low

779447

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.279

Low

793278

TAT1
Valine/tyrosine/tryptophan amino-acid permease 1

1

0

High-throughput

0.269

Low

1044976

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.269

Low

619175

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.249

Low

677547

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

679058

FUB1
Silencing boundary-establishment protein FUB1

1

0

High-throughput

0.249

Low

797048

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

808750

ATU2
Copper-transporting ATPase

1

0

High-throughput

0.249

Low

877897

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

1044967

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

1044974

ENB1
Siderophore iron transporter ENB1

1

0

High-throughput

0.249

Low

1044977

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

1044982

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low

1044983

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

923284

MNT4
Probable alpha-1,3-mannosyltransferase MNT4

1

0

High-throughput

0.238

Low

1044973

YL076
Putative uncharacterized protein YLR076C

1

0

Small-scale

0.238

Low

368353

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

0

High-throughput

0.232

Low

922973

ZNG1
Zinc-regulated GTPase metalloprotein activator 1

1

0

High-throughput

0.232

Low

924156

YNT3
Uncharacterized protein YNL193W

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025