HitPredict

Interactor 1: CDK19 (Q9BWU1)
Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase)
Gene: CDK19

Interactor 2: MED4 (Q9NPJ6)
Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)
Gene: MED4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	24981860, 33961781, 35271311, 26186194, 28514442, 32707033, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 502 Hs			1 270
+	Hs
		826361 CDK8_HUMAN (1-502): 1.77e-150: 439: 76.69		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Hs
		73043 B4DUB1_HUMAN (152-502): 1.59e-138: 406: 100.00		MED4_HUMAN (1-258): 3.31e-135: 384: 100.00
+	Dm
		1373436 CDK8_DROME (1-413): 7.19e-138: 407: 77.24		MED4_DROME (25-258): 6.66e-90: 268: 39.68