HitPredict

Interactor 1: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 1620
+	Hs
		215959 SYNJ1_HUMAN (38-463): 2.82e-42: 163: 11.55		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1124756 SRC8_HUMAN (291-502): 1.39e-34: 138: 20.72		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		710862 ABI1_HUMAN (1-508): 1.73e-123: 372: 100.00		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		840970 ABI1_HUMAN (1-508): 1.73e-123: 372: 100.00		ABL2_HUMAN (1103-1526): 1.43e-118: 405: 32.47
+	Mm
		73889 ABI1_MOUSE (1-508): 5.57e-122: 367: 91.93		B2RQ57_MOUSE (1103-1526): 5.23e-111: 381: 32.00
+	Hs
		840988 ABI2_HUMAN (1-508): 1.76e-80: 261: 59.84		ABL2_HUMAN (1103-1526): 1.43e-118: 405: 32.47
+	Mm
		582006 ABI1_MOUSE (1-508): 5.57e-122: 367: 91.93		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		1156993 ABI1_HUMAN (1-508): 1.73e-123: 372: 100.00		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		597899 ABI1_HUMAN (1-508): 1.73e-123: 372: 100.00		FER_HUMAN (1101-1377): 1.54e-59: 223: 40.35
+	Hs
		456112 ABI1_HUMAN (1-508): 1.73e-123: 372: 100.00		FES_HUMAN (1114-1384): 4.52e-59: 222: 42.80
+	Hs
		541585 ABI1_HUMAN (1-508): 1.73e-123: 372: 100.00		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		710833 SRC8_HUMAN (291-502): 1.39e-34: 138: 20.72		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		840957 SRC8_HUMAN (291-502): 1.39e-34: 138: 20.72		ABL2_HUMAN (1103-1526): 1.43e-118: 405: 32.47
+	Hs
		710627 SRC8_HUMAN (291-502): 1.39e-34: 138: 20.72		EPHA3_HUMAN (943-1427): 1.05e-119: 403: 25.05
+	Mm
		1455819 ASAP1_MOUSE (107-505): 1.95e-34: 140: 16.63		FAK2_MOUSE (1061-1496): 1.35e-110: 378: 28.31
+	Hs
		412709 ABI2_HUMAN (1-508): 1.76e-80: 261: 59.84		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		541719 ABI2_HUMAN (1-508): 1.76e-80: 261: 59.84		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		215899 SYNJ1_HUMAN (38-463): 2.82e-42: 163: 11.55		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		411923 SRC8_HUMAN (291-502): 1.39e-34: 138: 20.72		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		597890 SRC8_HUMAN (291-502): 1.39e-34: 138: 20.72		FER_HUMAN (1101-1377): 1.54e-59: 223: 40.35