HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: NR2E1 (Q9Y466)
Nuclear receptor subfamily 2 group E member 1 (Nuclear receptor TLX) (Protein tailless homolog) (Tll) (hTll)
Gene: NR2E1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	18391013, 28420882
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0042826 - histone deacetylase binding GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 385
+	Hs
		1110214 HDAC1_HUMAN (1-443): 0: 642: 90.07		NR2E1_HUMAN (1-385): 1.68e-135: 394: 100.00
+	Hs
		396641 HDAC2_HUMAN (1-488): 0: 707: 100.00		ESR1_HUMAN (8-385): 6.12e-98: 305: 29.06
+	Hs
		520611 HDAC2_HUMAN (1-488): 0: 707: 100.00		RARA_HUMAN (14-384): 1.48e-89: 279: 25.34
+	Mm
		1000012 HDAC2_MOUSE (1-488): 0: 704: 99.39		ERR2_MOUSE (11-383): 4.32e-90: 279: 28.95
+	Hs
		1366932 HDAC2_HUMAN (1-488): 0: 707: 100.00		ESR2_HUMAN (2-382): 4.93e-86: 272: 26.75
+	Mm
		148658 HDAC1_MOUSE (1-443): 0: 645: 90.29		RXRA_MOUSE (2-383): 6.58e-110: 331: 31.15
+	Hs
		188396 HDAC3_HUMAN (10-431): 0: 574: 58.26		NR2E1_HUMAN (1-385): 1.68e-135: 394: 100.00
+	Mm
		313125 HDAC3_MOUSE (10-431): 0: 574: 58.49		NR2E1_MOUSE (1-385): 2.04e-135: 393: 98.96
+	Hs
		665094 HDAC1_HUMAN (1-443): 0: 642: 90.07		COT2_HUMAN (5-383): 6.35e-102: 309: 34.83
+	Hs
		396057 HDAC1_HUMAN (1-443): 0: 642: 90.07		ESR1_HUMAN (8-385): 6.12e-98: 305: 29.06
+	Hs
		652511 HDAC1_HUMAN (1-443): 0: 642: 90.07		NR4A1_HUMAN (4-383): 4.31e-97: 302: 26.44
+	Mm
		148699 HDAC1_MOUSE (1-443): 0: 645: 90.29		ERR2_MOUSE (11-383): 4.32e-90: 279: 28.95
+	Hs
		520575 HDAC1_HUMAN (1-443): 0: 642: 90.07		RARA_HUMAN (14-384): 1.48e-89: 279: 25.34
+	Hs
		1109951 HDAC1_HUMAN (1-443): 0: 642: 90.07		ESR2_HUMAN (2-382): 4.93e-86: 272: 26.75
+	Hs
		188169 HDAC3_HUMAN (10-431): 0: 574: 58.26		RXRA_HUMAN (2-383): 6.9e-109: 329: 31.15
+	Hs
		188143 HDAC3_HUMAN (10-431): 0: 574: 58.26		ESR1_HUMAN (8-385): 6.12e-98: 305: 29.06
+	Hs
		188201 HDAC3_HUMAN (10-431): 0: 574: 58.26		HNF4A_HUMAN (2-383): 6.34e-98: 301: 30.16
+	Hs
		188153 HDAC3_HUMAN (10-431): 0: 574: 58.26		RARA_HUMAN (14-384): 1.48e-89: 279: 25.34
+	Hs
		188327 HDAC3_HUMAN (10-431): 0: 574: 58.26		ESR2_HUMAN (2-382): 4.93e-86: 272: 26.75
+	Mm
		147639 HDAC8_MOUSE (33-372): 1.47e-138: 405: 43.70		ERR1_MOUSE (16-382): 8.31e-35: 134: 30.40