HitPredict

Interactor 1: SEH1 (Q96EE3)
Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein)
Gene: SEH1L

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 360 Hs			1 1298
+	Hs
		965154 SEH1_HUMAN (1-360): 2.39e-78: 246: 100.00		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		965071 WDR5B_HUMAN (78-360): 1.43e-49: 170: 17.31		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		965141 FBXW7_HUMAN (94-360): 2.63e-46: 169: 10.82		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		845264 LIS1_HUMAN (91-357): 4.5e-46: 163: 15.68		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		302801 CIAO1_HUMAN (57-321): 2.69e-22: 98: 20.71		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		965151 SNR40_HUMAN (3-140): 1.03e-21: 96.4: 18.88		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		965276 NLE1_HUMAN (252-357): 2.69e-20: 93.7: 16.04		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		964797 WDR5_HUMAN (253-360): 1.76e-17: 84.1: 18.52		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Mm
		988931 LIS1_MOUSE (91-357): 3.19e-46: 164: 15.68		LIS1_MOUSE (123-363): 1.82e-35: 142: 12.30
+	Hs
		845250 LIS1_HUMAN (91-357): 4.5e-46: 163: 15.68		LIS1_HUMAN (123-363): 2.02e-35: 142: 12.30
+	At
		1247477 TAF5_ARATH (6-298): 1.46e-25: 109: 15.20		TAF5_ARATH (52-252): 1.74e-38: 156: 13.97
+	Hs
		1380064 FBXW7_HUMAN (94-360): 2.63e-46: 169: 10.82		FBXW7_HUMAN (164-314): 4.21e-18: 92.2: 10.53
+	Hs
		1334151 POC1A_HUMAN (98-354): 2.44e-50: 175: 13.62		POC1B_HUMAN (1-83): 2.36e-16: 85.7: 16.28
+	Hs
		845346 LIS1_HUMAN (91-357): 4.5e-46: 163: 15.68		KTNB1_HUMAN (167-610): 4.74e-17: 88.7: 8.64
+	Hs
		302772 CIAO1_HUMAN (57-321): 2.69e-22: 98: 20.71		LIS1_HUMAN (123-363): 2.02e-35: 142: 12.30
+	Sp
		1068486 TUP11_SCHPO (147-351): 3.43e-31: 126: 11.48		TUP12_SCHPO (171-368): 7.07e-13: 75.3: 9.81