HitPredict

Interactor 1: MAGI1 (Q96QZ7)
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3)
Gene: MAGI1

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, Guanylate_kin~SH3_2, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0005923 - bicellular tight junction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1491 Hs			1 1190
+	Hs
		1325307 MAGI1_HUMAN (1-1491): 0: 793: 100.00		PALS1_HUMAN (455-886): 1.78e-39: 159: 19.67
+	Hs
		168670 DLG4_HUMAN (14-112): 1.94e-16: 87.1: 19.23		CSKP_HUMAN (229-890): 7.83e-90: 312: 14.96
+	Rn
		723902 NHRF3_RAT (990-1260): 2e-49: 186: 20.30		DLG4_RAT (3-535): 2.23e-54: 205: 15.57
+	Mm
		1223740 MAGI3_MOUSE (2-1046): 9.6e-28: 124: 11.13		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Mm
		1223689 DLG2_MOUSE (6-111): 7.81e-17: 88.7: 18.92		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Hs
		1006071 DLG2_HUMAN (6-111): 1.43e-16: 87.9: 18.92		DLG4_HUMAN (3-535): 1.47e-54: 205: 15.57
+	Hs
		1006042 DLG4_HUMAN (14-112): 1.94e-16: 87.1: 19.23		DLG4_HUMAN (3-535): 1.47e-54: 205: 15.57
+	Mm
		1223542 DLG4_MOUSE (14-110): 3.22e-16: 86.3: 19.61		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Hs
		1091503 DLG2_HUMAN (6-111): 1.43e-16: 87.9: 18.92		DLG1_HUMAN (1-423): 1.41e-47: 186: 18.25
+	Rn
		1224262 DLG2_RAT (6-500): 5.15e-17: 89: 10.46		DLG1_RAT (1-423): 6.54e-44: 175: 18.48
+	Mm
		1223608 DLG4_MOUSE (14-110): 3.22e-16: 86.3: 19.61		DLG1_MOUSE (1-423): 1.07e-44: 177: 18.25
+	Rn
		723883 DLG4_RAT (14-112): 1.54e-16: 87.5: 19.23		DLG1_RAT (1-423): 6.54e-44: 175: 18.48
+	Hs
		1152416 DLG2_HUMAN (6-111): 1.43e-16: 87.9: 18.92		DLG3_HUMAN (2-123): 6.12e-23: 107: 27.42
+	Mm
		999796 DLG2_MOUSE (6-111): 7.81e-17: 88.7: 18.92		DLG3_MOUSE (2-360): 1.39e-22: 106: 15.93
+	Hs
		1006087 DLG4_HUMAN (14-112): 1.94e-16: 87.1: 19.23		DLG3_HUMAN (2-123): 6.12e-23: 107: 27.42
+	Rn
		723886 DLG4_RAT (14-112): 1.54e-16: 87.5: 19.23		DLG3_RAT (2-360): 1.37e-22: 106: 15.93
+	Mm
		1197968 DLG4_MOUSE (14-110): 3.22e-16: 86.3: 19.61		Q52KF7_MOUSE (2-123): 5.81e-23: 107: 27.42
+	Mm
		999787 DLG4_MOUSE (14-110): 3.22e-16: 86.3: 19.61		DLG3_MOUSE (2-360): 1.39e-22: 106: 15.93
+	Mm
		1190725 DLG4_MOUSE (14-110): 3.22e-16: 86.3: 19.61		Q3UP61_MOUSE (5-331): 2.16e-18: 93.3: 16.18