HitPredict

Interactor 1: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Interactor 2: M3K2 (Q9Y2U5)
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene: MAP3K2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33571521
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 400 Hs			1 619
+	Hs
		1407238 WWTR1_HUMAN (1-400): 5.18e-126: 371: 100.00		M3K3_HUMAN (1-615): 6.44e-178: 519: 64.59
+	Hs
		862572 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		M3K2_HUMAN (1-619): 0: 586: 100.00
+	Hs
		862408 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		M3K3_HUMAN (1-615): 6.44e-178: 519: 64.59
+	Hs
		1394640 ITCH_HUMAN (37-356): 2.66e-60: 211: 14.83		M3K2_HUMAN (1-619): 0: 586: 100.00
+	Mm
		109298 SMUF1_MOUSE (81-321): 5.33e-51: 184: 18.70		G5E8L8_MOUSE (1-619): 0: 593: 96.28
+	Hs
		1439017 SMUF1_HUMAN (55-362): 3.98e-51: 184: 16.62		M3K2_HUMAN (1-619): 0: 586: 100.00
+	Hs
		1407242 SMUF1_HUMAN (55-362): 3.98e-51: 184: 16.62		M3K3_HUMAN (1-615): 6.44e-178: 519: 64.59
+	Hs
		862094 YAP1_HUMAN (14-400): 3.69e-97: 300: 41.13		PAK2_HUMAN (106-617): 4.89e-129: 391: 24.33
+	Hs
		861850 NEDD4_HUMAN (109-352): 7.43e-23: 103: 11.00		M3K2_HUMAN (1-619): 0: 586: 100.00
+	Hs
		1400054 NED4L_HUMAN (164-352): 3.04e-13: 73.5: 13.20		M3K2_HUMAN (1-619): 0: 586: 100.00
+	Hs
		861745 NEDD4_HUMAN (109-352): 7.43e-23: 103: 11.00		M3K3_HUMAN (1-615): 6.44e-178: 519: 64.59
+	Hs
		1399993 NED4L_HUMAN (164-352): 3.04e-13: 73.5: 13.20		M3K3_HUMAN (1-615): 6.44e-178: 519: 64.59
+	Hs
		176866 MAGI1_HUMAN (10-212): 9.43e-40: 153: 15.74		DCLK1_HUMAN (22-618): 9.51e-135: 412: 16.72
+	Hs
		861844 NEDD4_HUMAN (109-352): 7.43e-23: 103: 11.00		AKT3_HUMAN (292-616): 4.46e-124: 377: 24.47
+	Hs
		1400053 NED4L_HUMAN (164-352): 3.04e-13: 73.5: 13.20		AKT3_HUMAN (292-616): 4.46e-124: 377: 24.47