Protein: SMUF1
E3 ubiquitin-protein ligase SMURF1 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)

Gene: SMUF1, Smurf1
Organism: Mus musculus
Interactions: 22
UniProt ID: Q9CUN6

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1000237

SMAD1
Mothers against decapentaplegic homolog 1

3

20

Small-scale

0.642

High

1423816

OASL2
2'-5'-oligoadenylate synthase-like protein 2

1

20

Small-scale

0.618

High

204424

SMAD6
Mothers against decapentaplegic homolog 6

2

20

Small-scale

0.584

High

109298

G5E8L8
mitogen-activated protein kinase kinase kinase

1

13

Small-scale

0.573

High

204553

SMAD7
Mothers against decapentaplegic homolog 7

1

20

Small-scale

0.479

High

641294

FGFR2
Fibroblast growth factor receptor 2

1

20

Small-scale

0.479

High

662996

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.479

High

789700

PPARG
Peroxisome proliferator-activated receptor gamma

1

11

Small-scale

0.479

High

1064944

RUNX2
Runt-related transcription factor 2

1

11

Small-scale

0.479

High

1221615

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

Small-scale

0.479

High

1224009

TGFR2
TGF-beta receptor type-2

1

19

High-throughput

0.479

High

1281828

GPBAR
G-protein coupled bile acid receptor 1

1

1

Small-scale

0.479

High

1296289

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

7

High-throughput

0.479

High

1298001

TSSK5
Testis-specific serine/threonine-protein kinase 5

1

19

Small-scale

0.479

High

1353880

MAVS
Mitochondrial antiviral-signaling protein

1

11

Small-scale

0.479

High

1423814

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.479

High

1423815

PAR6A
Partitioning defective 6 homolog alpha

1

15

Small-scale

0.479

High

940748

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

9

Small-scale

0.437

High

942139

WFS1
Wolframin

1

2

Small-scale

0.437

High

1354080

SETD7
Histone-lysine N-methyltransferase SETD7

1

5

Small-scale

0.437

High

1317429

TRIB3
Tribbles homolog 3

1

19

Small-scale

0.417

High

1224667

EGLN
Endoglin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025