HitPredict

Interactor 1: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	35384245, 34273398
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0046777 - protein autophosphorylation
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1746 Hs			1 1620
+	Hs
		464055 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		RET_HUMAN (804-1477): 5.87e-139: 460: 23.15
+	Hs
		710892 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		710663 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		EPHA3_HUMAN (943-1427): 1.05e-119: 403: 25.05
+	Hs
		465650 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77
+	Rn
		93252 D4A563_RAT (1-1746): 0: 2074: 85.98		INSR_RAT (973-1484): 1.46e-112: 392: 32.38
+	Hs
		1159541 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44
+	Hs
		412620 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		541686 PEAK1_HUMAN (1-1746): 0: 2185: 100.00		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Mm
		591088 KPCE_MOUSE (1352-1719): 4.42e-92: 318: 13.12		FAK2_MOUSE (1061-1496): 1.35e-110: 378: 28.31
+	Hs
		465423 AKT1_HUMAN (1362-1695): 4.45e-91: 307: 15.07		IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77
+	Hs
		1034991 KPCE_HUMAN (1354-1719): 3.23e-92: 318: 13.98		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		541360 AKT1_HUMAN (1362-1695): 4.45e-91: 307: 15.07		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		541322 KAPCA_HUMAN (1345-1709): 1.11e-90: 301: 18.30		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		1125284 PEAK3_HUMAN (1653-1743): 1.23e-30: 129: 38.46		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		541542 OBSCN_HUMAN (933-1713): 2.28e-56: 219: 11.37		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07