Protein: PEAK1
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)

Gene: PEAK1
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q9H792

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005829 - cytosol
GO:0005925 - focal adhesion
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

170357

AURKA
Aurora kinase A

3

18

High-throughput

0.861

High

375957

RASK
GTPase KRas

3

10

High-throughput

0.827

High

1435589

ALK
ALK tyrosine kinase receptor

2

15

High-throughput

0.776

High

976565

RB11A
Ras-related protein Rab-11A

2

2

High-throughput

0.754

High

978309

RHOB
Rho-related GTP-binding protein RhoB

2

19

High-throughput

0.754

High

786856

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

8

15

High-throughput

0.748

High

967975

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

5

15

High-throughput

0.723

High

855756

CRK
Adapter molecule crk

5

18

Small-scale

0.714

High

987945

GRB2
Growth factor receptor-bound protein 2

4

19

High-throughput

0.697

High

834230

CSK
Tyrosine-protein kinase CSK

1

15

High-throughput

0.691

High

222208

NCK2
Cytoplasmic protein NCK2

4

20

High-throughput

0.691

High

1435583

SH22A
SH2 domain-containing protein 2A

3

20

High-throughput

0.667

High

1435590

CARD8
Caspase recruitment domain-containing protein 8

3

2

High-throughput

0.667

High

966879

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

1049789

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1163977

DDR2
Discoidin domain-containing receptor 2

1

19

High-throughput

0.646

High

711416

SHC1
SHC-transforming protein 1

2

16

High-throughput

0.628

High

855939

CRKL
Crk-like protein

2

20

High-throughput

0.628

High

126804

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

363865

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

401487

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

High-throughput

0.618

High

412620

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.618

High

440212

LCK
Tyrosine-protein kinase Lck

1

11

High-throughput

0.618

High

463772

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.618

High

465650

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.618

High

466464

RHOC
Rho-related GTP-binding protein RhoC

1

18

High-throughput

0.618

High

468810

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

541686

FGFR1
Fibroblast growth factor receptor 1

1

17

High-throughput

0.618

High

581294

RAC2
Ras-related C3 botulinum toxin substrate 2

1

17

High-throughput

0.618

High

593498

PGFRA
Platelet-derived growth factor receptor alpha

1

10

High-throughput

0.618

High

631479

RAB5A
Ras-related protein Rab-5A

1

7

High-throughput

0.618

High

648676

FGFR4
Fibroblast growth factor receptor 4

1

19

High-throughput

0.618

High

710496

EPHA2
Ephrin type-A receptor 2

1

15

High-throughput

0.618

High

710663

EPHA3
Ephrin type-A receptor 3

1

15

High-throughput

0.618

High

710892

EPHB2
Ephrin type-B receptor 2

1

14

High-throughput

0.618

High

845807

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

891314

GSK3A
Glycogen synthase kinase-3 alpha

1

11

High-throughput

0.618

High

891791

GSK3B
Glycogen synthase kinase-3 beta

1

10

High-throughput

0.618

High

902074

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.618

High

910199

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

920278

PLK1
Serine/threonine-protein kinase PLK1

1

13

High-throughput

0.618

High

936450

AFAD
Afadin

1

5

High-throughput

0.618

High

953101

ACTB
Actin, cytoplasmic 1

1

16

High-throughput

0.618

High

953677

RAC3
Ras-related C3 botulinum toxin substrate 3

1

19

High-throughput

0.618

High

955601

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

956493

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.618

High

962492

RHOA
Transforming protein RhoA

1

19

High-throughput

0.618

High

962830

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

988711

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015790

RHOG
Rho-related GTP-binding protein RhoG

1

18

High-throughput

0.618

High

1091463

ANK3
Ankyrin-3

1

4

High-throughput

0.618

High

1107215

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.618

High

1140870

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.618

High

1144668

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

3

High-throughput

0.618

High

1145113

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.618

High

1159541

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

1270997

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1366885

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1432969

DNJC5
DnaJ homolog subfamily C member 5

1

6

High-throughput

0.618

High

1435582

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1311523

BBS7
BBSome complex member BBS7

2

0

High-throughput

0.602

High

407712

S100B
Protein S100-B

2

11

High-throughput

0.601

High

880964

MTR1B
Melatonin receptor type 1B

1

1

High-throughput

0.587

High

1208577

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.586

High

540678

LAMP1
Lysosome-associated membrane glycoprotein 1

2

4

High-throughput

0.584

High

582962

EZRI
Ezrin

2

8

High-throughput

0.584

High

541059

PIM1
Serine/threonine-protein kinase pim-1

1

19

High-throughput

0.575

High

1435581

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

18

Small-scale

0.575

High

1352206

DQX1
ATP-dependent RNA helicase homolog DQX1

2

6

High-throughput

0.574

High

1413491

AASD1
Alanyl-tRNA editing protein Aarsd1

2

3

High-throughput

0.574

High

1435591

PCDBB
Protocadherin beta-11

2

4

High-throughput

0.574

High

730246

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.571

High

1421262

RHG39
Rho GTPase-activating protein 39

2

7

High-throughput

0.571

High

341144

DIRA3
GTP-binding protein Di-Ras3

1

7

High-throughput

0.553

High

464055

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

16

High-throughput

0.553

High

601447

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

630973

RAB4A
Ras-related protein Rab-4A

1

6

High-throughput

0.553

High

931898

EPHA5
Ephrin type-A receptor 5

1

18

High-throughput

0.553

High

945100

RAB25
Ras-related protein Rab-25

1

5

High-throughput

0.553

High

1004201

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.553

High

1034346

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

19

High-throughput

0.553

High

1147433

EPHA7
Ephrin type-A receptor 7

1

12

High-throughput

0.553

High

1151877

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.553

High

1396628

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1433509

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

549684

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

3

High-throughput

0.536

High

559498

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.536

High

867422

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.536

High

1052104

CALD1
Caldesmon

1

20

High-throughput

0.536

High

1124725

SRC8
Src substrate cortactin

1

7

High-throughput

0.536

High

1382381

SPSB4
SPRY domain-containing SOCS box protein 4

1

12

High-throughput

0.536

High

1431476

CAD23
Cadherin-23

1

3

High-throughput

0.536

High

1435288

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

516587

CALM3
Calmodulin-3

1

9

High-throughput

0.514

High

1335384

CAMKV
CaM kinase-like vesicle-associated protein

1

6

High-throughput

0.514

High

1099783

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1405051

SORT
Sortilin

1

0

High-throughput

0.513

High

1435592

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

0

High-throughput

0.513

High

942890

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

Small-scale

0.500

High

220103

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

4

High-throughput

0.489

High

665286

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.489

High

852317

MMP13
Collagenase 3

1

2

High-throughput

0.489

High

1206899

TOIP1
Torsin-1A-interacting protein 1

1

1

High-throughput

0.489

High

1307360

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

3

High-throughput

0.489

High

1435585

FBLN5
Fibulin-5

1

4

High-throughput

0.489

High

226207

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

299375

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

459756

PROF1
Profilin-1

1

2

High-throughput

0.479

High

556347

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

604208

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

613462

VINC
Vinculin

1

10

High-throughput

0.479

High

614734

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

5

High-throughput

0.479

High

691437

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

715780

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

730891

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

764433

CTNA1
Catenin alpha-1

1

5

High-throughput

0.479

High

878562

PAXI
Paxillin

1

16

High-throughput

0.479

High

896638

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

972004

1433E
14-3-3 protein epsilon

1

11

High-throughput

0.479

High

975247

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.479

High

990741

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1041295

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

1058937

ZO1
Tight junction protein 1

1

3

High-throughput

0.479

High

1087288

STX4
Syntaxin-4

1

5

High-throughput

0.479

High

1156215

ZYX
Zyxin

1

11

High-throughput

0.479

High

1187565

AR13B
ADP-ribosylation factor-like protein 13B

1

9

High-throughput

0.479

High

1254040

PEAK3
Protein PEAK3

1

3

Small-scale

0.479

High

1368954

GOGA1
Golgin subfamily A member 1

1

12

High-throughput

0.479

High

1428973

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1435586

ZO2
Tight junction protein 2

1

3

High-throughput

0.479

High

1435587

ANC2
Anaphase-promoting complex subunit 2

1

10

High-throughput

0.479

High

594103

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.445

High

1395166

HIPL1
HHIP-like protein 1

1

2

High-throughput

0.445

High

189844

STX7
Syntaxin-7

1

2

High-throughput

0.437

High

218784

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

353559

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

562398

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.437

High

643074

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

1147682

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

3

High-throughput

0.437

High

1159850

OCLN
Occludin

1

1

High-throughput

0.437

High

1163667

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

4

High-throughput

0.437

High

1229085

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.437

High

1276320

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.437

High

1322989

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.437

High

1367282

ESR2
Estrogen receptor beta

1

13

High-throughput

0.437

High

1326553

CARME
Carnosine N-methyltransferase

1

0

High-throughput

0.426

High

1103379

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.407

High

1258583

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

4

High-throughput

0.407

High

1388499

ZMY19
Zinc finger MYND domain-containing protein 19

1

1

High-throughput

0.407

High

1435584

WRP73
WD repeat-containing protein WRAP73

1

2

High-throughput

0.407

High

1435588

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.407

High

139414

VMA5A
von Willebrand factor A domain-containing protein 5A

2

0

High-throughput

0.328

High

190486

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

139988

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

327451

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

1233486

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1381967

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1181434

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025