HitPredict

Interactor 1: PKHA1 (Q9HB21)
Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1)
Gene: PLEKHA1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35384245, 34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 404 Hs			1 1620
+	Hs
		1437684 PKHA5_HUMAN (130-342): 1.6e-33: 135: 20.55		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		710895 PKHA1_HUMAN (1-404): 4.74e-120: 356: 100.00		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		439850 PKHA1_HUMAN (1-404): 4.74e-120: 356: 100.00		INSR_HUMAN (973-1436): 1e-112: 392: 34.25
+	Hs
		465655 PKHA1_HUMAN (1-404): 4.74e-120: 356: 100.00		IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77
+	Hs
		412636 PKHA1_HUMAN (1-404): 4.74e-120: 356: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1157072 PKHA1_HUMAN (1-404): 4.74e-120: 356: 100.00		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Mm
		1222818 ASAP2_MOUSE (53-325): 8.17e-40: 153: 11.39		ERBB4_MOUSE (882-1541): 6.8e-121: 414: 21.23
+	Hs
		541695 PKHA1_HUMAN (1-404): 4.74e-120: 356: 100.00		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		710894 PKHA5_HUMAN (130-342): 1.6e-33: 135: 20.55		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Hs
		207921 ASAP2_HUMAN (53-325): 4.03e-38: 148: 11.15		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		465652 PKHA5_HUMAN (130-342): 1.6e-33: 135: 20.55		IGF1R_HUMAN (1037-1385): 8.56e-111: 386: 39.77
+	Hs
		286772 SKAP2_HUMAN (95-356): 3.38e-34: 132: 12.50		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		412280 DP13B_HUMAN (31-397): 1.11e-42: 160: 13.81		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		541589 AFAP1_HUMAN (6-399): 3.95e-47: 173: 13.70		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		207902 ASAP2_HUMAN (53-325): 4.03e-38: 148: 11.15		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		412871 FARP1_HUMAN (19-303): 3.66e-38: 148: 12.24		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1157070 PKHA5_HUMAN (130-342): 1.6e-33: 135: 20.55		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Hs
		541777 FARP1_HUMAN (19-303): 3.66e-38: 148: 12.24		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		541549 PKHA7_HUMAN (105-397): 4.38e-34: 136: 17.24		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07
+	Hs
		541693 PKHA5_HUMAN (130-342): 1.6e-33: 135: 20.55		FGFR1_HUMAN (1110-1403): 6.78e-55: 209: 38.07