Protein: AFAP1
Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110)

Gene: AFAP1
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q8N556

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003779 - actin binding
GO:0005829 - cytosol
GO:0005884 - actin filament
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1327352

ANLN
Anillin

3

1

High-throughput

0.847

High

1327359

AKT3
RAC-gamma serine/threonine-protein kinase

1

3

High-throughput

0.691

High

171735

GAK
Cyclin-G-associated kinase

1

0

High-throughput

0.656

High

667934

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.656

High

424669

KPCG
Protein kinase C gamma type

1

5

Small-scale

0.647

High

436702

KPCB
Protein kinase C beta type

1

5

Small-scale

0.647

High

603308

KPCA
Protein kinase C alpha type

1

5

Small-scale

0.647

High

1035007

KPCE
Protein kinase C epsilon type

1

5

Small-scale

0.647

High

1051944

KPCD
Protein kinase C delta type

1

5

Small-scale

0.647

High

891246

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.618

High

891676

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.618

High

1327351

RHOF
Rho-related GTP-binding protein RhoF

1

1

High-throughput

0.618

High

1327341

AFAP1
Actin filament-associated protein 1

1

0

Small-scale

0.614

High

541589

FGFR1
Fibroblast growth factor receptor 1

1

0

Small-scale

0.586

High

955373

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.586

High

1140557

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.586

High

1327350

ECT2
Protein ECT2

1

0

High-throughput

0.586

High

396503

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

123769

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.536

High

1327347

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.536

High

656186

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

2

High-throughput

0.515

High

637630

FLNA
Filamin-A

1

0

High-throughput

0.513

High

772903

MYH9
Myosin-9

1

0

High-throughput

0.513

High

862904

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.513

High

866758

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

968378

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

High-throughput

0.513

High

1152154

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

1160687

DREB
Drebrin

1

0

High-throughput

0.513

High

1325422

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

1327353

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.513

High

1327356

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.513

High

1327358

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

1327342

MY18A
Unconventional myosin-XVIIIa

1

1

High-throughput

0.489

High

995696

ACTC
Actin, alpha cardiac muscle 1

1

0

Small-scale

0.480

High

223175

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

986563

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

990496

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.479

High

1327355

TES
Testin

1

1

High-throughput

0.479

High

904927

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

958999

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

995138

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1045517

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1115297

CUL4B
Cullin-4B

1

0

Small-scale

0.458

High

1327348

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1327349

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

331142

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.437

High

1118094

DX39B
Spliceosome RNA helicase DDX39B

1

1

Small-scale

0.437

High

1327343

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

530077

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1103271

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.407

High

1327345

EXT2
Exostosin-2

2

0

High-throughput

0.328

High

372571

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.318

High

630318

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.279

Low

1327346

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.279

Low

219330

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.249

Low

247996

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

649363

H1T
Histone H1t

1

0

High-throughput

0.249

Low

799293

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

1254634

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1327344

DPF3
Zinc finger protein DPF3

1

0

High-throughput

0.249

Low

1327354

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

1327357

XPO7
Exportin-7

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025