HitPredict

Interactor 1: XPOT (O43592)
Exportin-T (Exportin(tRNA)) (tRNA exportin)
Gene: XPOT

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.916

Property	Details
Experiments	32296183, 12138183, 11024021, 10944119, unassigned1304
Identification Methods	two hybrid, pull down, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Exportin-T~Ras, IBN_N~Ras, Ras~Xpo1
Common GO terms	GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 962 Hs			1 216
+	Sp
		292805 XPOT_SCHPO (2-961): 4.72e-151: 474: 25.23		SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84
+	Hs
		162599 XPO1_HUMAN (1-961): 1.34e-151: 477: 14.33		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		675912 XPO1_YEAST (1-961): 2.81e-132: 427: 13.43		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	Dm
		1373317 Q9VRV8_DROME (2-953): 2.31e-123: 398: 12.24		RANL_DROME (1-210): 2.56e-93: 273: 60.48
+	At
		784987 MOS14_ARATH (2-942): 7.45e-114: 374: 13.62		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	Hs
		919198 TNPO1_HUMAN (10-919): 7.97e-129: 413: 12.88		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Hs
		155560 TNPO2_HUMAN (10-919): 8.28e-122: 394: 12.34		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	At
		784988 TNPO1_ARATH (1-855): 9.2e-106: 351: 13.35		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	At
		784992 IMB1_ARATH (1-880): 4.8e-100: 335: 11.53		RAN1_ARATH (1-216): 1.39e-95: 279: 73.52
+	Hs
		297168 IPO13_HUMAN (2-961): 2.27e-110: 365: 12.77		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698755 XPOT_YEAST (10-961): 2.56e-103: 349: 17.72		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	At
		784999 IMB1_ARATH (1-880): 4.8e-100: 335: 11.53		RAN2_ARATH (1-215): 1.36e-88: 261: 74.77
+	Sc
		699000 XPOT_YEAST (10-961): 2.56e-103: 349: 17.72		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Hs
		919273 XPO5_HUMAN (1-879): 3.25e-103: 350: 13.26		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00
+	Sc
		698996 MTR10_YEAST (3-957): 3.18e-100: 338: 14.80		GSP1_YEAST (1-214): 5.23e-83: 247: 80.56
+	At
		1210454 IMB1_ARATH (1-880): 4.8e-100: 335: 11.53		RAN3_ARATH (1-215): 9.1e-84: 249: 74.31
+	Hs
		914368 XPO5_HUMAN (1-879): 3.25e-103: 350: 13.26		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Sc
		699022 MTR10_YEAST (3-957): 3.18e-100: 338: 14.80		GSP2_YEAST (1-214): 1.18e-80: 241: 79.72
+	Hs
		919228 XPO6_HUMAN (13-957): 5.43e-85: 298: 11.17		RAN_HUMAN (1-216): 7.75e-79: 237: 100.00