Protein: SKAP2
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)

Gene: SKAP2
Organism: Homo sapiens
Interactions: 52
UniProt ID: O75563

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

286751

FYN
Tyrosine-protein kinase Fyn

5

20

Small-scale

0.917

High

286777

SKAP1
Src kinase-associated phosphoprotein 1

3

19

High-throughput

0.861

High

286764

RGS3
Regulator of G-protein signaling 3

2

8

High-throughput

0.811

High

286772

FAK2
Protein-tyrosine kinase 2-beta

2

20

Small-scale

0.793

High

178064

FYB1
FYN-binding protein 1

2

15

Small-scale

0.793

High

286757

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.767

High

286753

LYN
Tyrosine-protein kinase Lyn

2

20

Small-scale

0.757

High

286754

HCK
Tyrosine-protein kinase HCK

2

20

Small-scale

0.757

High

286748

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.752

High

160369

IRS4
Insulin receptor substrate 4

1

4

High-throughput

0.691

High

286767

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.691

High

286770

SNTB2
Beta-2-syntrophin

1

20

High-throughput

0.691

High

286771

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

12

High-throughput

0.691

High

286785

TMPSD
Transmembrane protease serine 13

1

3

High-throughput

0.691

High

286786

TARA
TRIO and F-actin-binding protein

1

15

High-throughput

0.691

High

286768

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

8

High-throughput

0.628

High

221989

NCK2
Cytoplasmic protein NCK2

1

20

Small-scale

0.621

High

286747

SKAP2
Src kinase-associated phosphoprotein 2

1

18

Small-scale

0.621

High

286750

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.621

High

286752

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.621

High

286755

FGR
Tyrosine-protein kinase Fgr

1

20

Small-scale

0.621

High

286761

FRK
Tyrosine-protein kinase FRK

1

20

Small-scale

0.621

High

286765

BLK
Tyrosine-protein kinase Blk

1

20

Small-scale

0.621

High

286787

SRMS
Tyrosine-protein kinase Srms

1

20

Small-scale

0.621

High

286779

ABHD5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5

2

0

High-throughput

0.602

High

286791

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

20

Small-scale

0.586

High

286778

FRMD1
FERM domain-containing protein 1

2

18

High-throughput

0.574

High

274407

DNJB6
DnaJ homolog subfamily B member 6

1

13

High-throughput

0.541

High

286756

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

12

High-throughput

0.536

High

286758

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

4

High-throughput

0.536

High

286762

RPGP1
Rap1 GTPase-activating protein 1

1

5

High-throughput

0.536

High

286784

AFG2B
ATPase family gene 2 protein homolog B

1

6

High-throughput

0.536

High

286792

FBX7
F-box only protein 7

1

1

High-throughput

0.536

High

286776

FYB2
FYN-binding protein 2

1

6

High-throughput

0.515

High

286780

XPF
DNA repair endonuclease XPF

1

0

High-throughput

0.513

High

286789

GBA2
Non-lysosomal glucosylceramidase

1

0

High-throughput

0.513

High

286749

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

286763

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

3

Small-scale

0.501

High

286773

ZN174
Zinc finger protein 174

1

2

High-throughput

0.489

High

286788

AT133
Polyamine-transporting ATPase 13A3

1

8

High-throughput

0.489

High

286775

EEIG1
Early estrogen-induced gene 1 protein

1

1

Small-scale

0.481

High

286759

H2B1O
Histone H2B type 1-O

1

6

High-throughput

0.479

High

286760

PSA4
Proteasome subunit alpha type-4

1

7

High-throughput

0.479

High

286766

H2BFS
Histone H2B type F-S

1

6

High-throughput

0.479

High

286774

H2B2F
Histone H2B type 2-F

1

6

High-throughput

0.479

High

286782

PRAM
PML-RARA-regulated adapter molecule 1

1

10

Small-scale

0.479

High

286783

H2B1N
Histone H2B type 1-N

1

6

High-throughput

0.479

High

286781

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

286790

S27A6
Long-chain fatty acid transport protein 6

1

3

High-throughput

0.445

High

183898

S22A2
Solute carrier family 22 member 2

1

0

High-throughput

0.426

High

286769

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

10

Small-scale

0.408

High


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Last updated: 11Aug2025