Protein: DID2
Vacuolar protein-sorting-associated protein 46 (Charged multivesicular body protein 1) (DOA4-independent degradation protein 2) (Fifty two inhibitor 1)

Gene: DID2
Organism: Saccharomyces cerevisiae S288C
Interactions: 69
UniProt ID: P69771

Gene Ontology (top 5):
GO:0000815 - ESCRT III complex
GO:0005737 - cytoplasm
GO:0005770 - late endosome
GO:0005771 - multivesicular body
GO:0006623 - protein targeting to vacuole

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

923806

IST1
Vacuolar protein sorting-associated protein IST1

9

13

Small-scale

0.970

High

999496

VTA1
Vacuolar protein sorting-associated protein VTA1

6

1

Small-scale

0.947

High

781332

DID4
DOA4-independent degradation protein 4

5

17

Small-scale

0.916

High

815044

SNF7
Vacuolar-sorting protein SNF7

5

20

Small-scale

0.916

High

781015

VPS24
Vacuolar protein-sorting-associated protein 24

5

18

Small-scale

0.909

High

999492

VPS60
Vacuolar protein-sorting-associated protein 60

3

20

Small-scale

0.827

High

999490

DID2
Vacuolar protein-sorting-associated protein 46

2

18

Small-scale

0.791

High

915378

VPS4
Vacuolar protein sorting-associated protein 4

12

20

Small-scale

0.759

High

999493

VPS20
Vacuolar protein sorting-associated protein 20

2

20

Small-scale

0.754

High

864574

YJE9
Uncharacterized protein YJL049W

1

2

Small-scale

0.618

High

597244

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.481

High

724304

ZIP1
Synaptonemal complex protein ZIP1

1

1

High-throughput

0.481

High

753127

NIP80
Protein NIP100

1

3

High-throughput

0.481

High

999501

SLK19
Kinetochore protein SLK19

1

1

High-throughput

0.481

High

646683

VPS15
Serine/threonine-protein kinase VPS15

1

1

High-throughput

0.479

High

649845

VPS34
Phosphatidylinositol 3-kinase VPS34

1

2

High-throughput

0.479

High

673308

ADP1
Probable ATP-dependent permease

1

1

High-throughput

0.479

High

795491

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

850420

ATG18
Autophagy-related protein 18

1

1

High-throughput

0.479

High

865450

VPS55
Vacuolar protein sorting-associated protein 55

1

2

Small-scale

0.479

High

874375

BRO1
Vacuolar-sorting protein BRO1

1

1

High-throughput

0.479

High

999491

BECN1
Vacuolar protein sorting-associated protein 30

1

1

High-throughput

0.479

High

999502

VPS68
Vacuolar protein sorting-associated protein 68

1

2

High-throughput

0.479

High

646072

KIN3
Serine/threonine-protein kinase KIN3

1

0

High-throughput

0.460

High

735653

SMY1
Kinesin-related protein SMY1

1

0

High-throughput

0.460

High

803305

ETP1
RING finger protein ETP1

1

0

High-throughput

0.460

High

805359

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

High-throughput

0.460

High

999497

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

448327

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

733817

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

0

High-throughput

0.458

High

812561

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

524839

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

545900

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

548230

BIK1
Nuclear fusion protein BIK1

1

2

High-throughput

0.439

High

758133

CASP
Protein CASP

1

1

High-throughput

0.439

High

844480

GZF3
Protein GZF3

1

1

High-throughput

0.439

High

924236

IPI3
Pre-rRNA-processing protein IPI3

1

2

High-throughput

0.439

High

999495

FAR8
Factor arrest protein 8

1

1

High-throughput

0.439

High

582505

SEC23
Protein transport protein SEC23

1

3

High-throughput

0.437

High

679960

CDC48
Cell division control protein 48

1

1

High-throughput

0.437

High

705215

PEX3
Peroxisomal biogenesis factor 3

1

2

High-throughput

0.437

High

707898

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

720847

ITR1
Myo-inositol transporter 1

1

1

High-throughput

0.437

High

748500

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

797189

ATG14
Autophagy-related protein 14

1

1

High-throughput

0.437

High

825237

SEC24
Protein transport protein SEC24

1

3

High-throughput

0.437

High

863821

ATG27
Autophagy-related protein 27

1

2

High-throughput

0.437

High

919625

TNA1
High-affinity nicotinic acid transporter

1

1

High-throughput

0.437

High

932209

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.437

High

999494

SEC13
Protein transport protein SEC13

1

2

High-throughput

0.437

High

999499

ATG23
Autophagy-related protein 23

1

2

High-throughput

0.437

High

999504

TMS1
Membrane protein TMS1

1

2

Small-scale

0.437

High

999505

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.437

High

823018

ATAD2
ATPase histone chaperone YTA7

1

2

High-throughput

0.407

High

506469

U5072
UPF0507 protein YML002W

1

0

Small-scale

0.251

Low

737019

CDC3
Cell division control protein 3

1

0

High-throughput

0.251

Low

749709

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low

755279

NUF2
Kinetochore protein NUF2

1

0

High-throughput

0.251

Low

777094

BDF1
Bromodomain-containing factor 1

1

0

High-throughput

0.251

Low

813833

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.251

Low

999498

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.251

Low

999500

IMH1
Golgin IMH1

1

0

High-throughput

0.251

Low

999503

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.251

Low

999506

NYV1
Vacuolar v-SNARE NYV1

1

0

High-throughput

0.251

Low

556581

STE6
Alpha-factor-transporting ATPase

1

0

High-throughput

0.249

Low

747702

ATO2
Ammonia transport outward protein 2

1

0

High-throughput

0.249

Low

826736

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

830111

FKS2
1,3-beta-glucan synthase component GSC2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025