HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: IRS2 (Q9Y4H2)
Insulin receptor substrate 2 (IRS-2)
Gene: IRS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15514089
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 1338
+	Mm
		639440 LYN_MOUSE (14-223): 3.04e-46: 161: 16.53		IRS2_MOUSE (1-1338): 2.79e-152: 496: 83.20
+	Hs
		146670 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		147396 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		412057 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		IRS1_HUMAN (21-1195): 9.72e-82: 296: 32.47
+	Hs
		151692 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		151689 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		146566 SOCS2_HUMAN (3-221): 1.16e-46: 154: 28.31		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Hs
		147457 SOCS6_HUMAN (15-220): 4.58e-39: 143: 22.64		IRS4_HUMAN (26-1066): 1.14e-74: 274: 21.72
+	Dm
		186292 O18683_DROME (18-158): 2.65e-38: 140: 17.02		IRS1_DROME (27-983): 1.28e-75: 274: 17.98
+	Mm
		101424 LYN_MOUSE (14-223): 3.04e-46: 161: 16.53		F8VPR5_MOUSE (279-1288): 2.62e-42: 172: 11.74
+	Hs
		442866 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		CBP_HUMAN (278-1288): 4.81e-39: 161: 12.20
+	Hs
		433930 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		CBP_HUMAN (278-1288): 4.81e-39: 161: 12.20
+	Hs
		523092 SRC_HUMAN (35-219): 4.06e-46: 161: 17.13		CBP_HUMAN (278-1288): 4.81e-39: 161: 12.20
+	Mm
		101430 CSK_MOUSE (3-220): 2.58e-38: 139: 12.45		F8VPR5_MOUSE (279-1288): 2.62e-42: 172: 11.74
+	Hs
		433560 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		MUC1_HUMAN (289-926): 1.69e-34: 146: 14.46
+	Hs
		522749 SRC_HUMAN (35-219): 4.06e-46: 161: 17.13		MUC1_HUMAN (289-926): 1.69e-34: 146: 14.46
+	Hs
		411582 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		MUC1_HUMAN (289-926): 1.69e-34: 146: 14.46
+	Hs
		297808 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		K0754_HUMAN (846-1326): 4.64e-29: 129: 11.90
+	Hs
		412362 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		MAGE1_HUMAN (729-1177): 8.9e-12: 72.1: 15.30
+	Hs
		434048 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		DAPLE_HUMAN (303-786): 4.42e-09: 63.4: 12.02