HitPredict

Interactor 1: CTRO (O14578)
Citron Rho-interacting kinase (CRIK) (EC 2.7.11.1) (Serine/threonine-protein kinase 21)
Gene: CIT

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.856

Property	Details
Experiments	8543060, 12773565, 31871319
Identification Methods	far western blotting, pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0032467 - positive regulation of cytokinesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2027 Hs			1 193
+	Hs
		148653 CTRO_HUMAN (1-2027): 0: 1212: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		148297 CTRO_HUMAN (1-2027): 0: 1212: 100.00		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Hs
		148632 CTRO_HUMAN (1-2027): 0: 1212: 100.00		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Rn
		92842 CTRO_RAT (1-2027): 0: 1136: 93.58		RHOA_RAT (1-193): 4.1e-81: 240: 99.48
+	Mm
		823539 CTRO_MOUSE (1-2027): 0: 1113: 93.68		RHOA_MOUSE (1-193): 4.1e-81: 240: 99.48
+	Mm
		823530 CTRO_MOUSE (1-2027): 0: 1113: 93.68		RAC1_MOUSE (1-193): 8.86e-80: 237: 57.22
+	Mm
		823529 CTRO_MOUSE (1-2027): 0: 1113: 93.68		CDC42_MOUSE (1-193): 5.51e-77: 230: 52.33
+	Hs
		925229 DMPK_HUMAN (58-548): 2.15e-125: 411: 34.33		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		616691 KS6B1_HUMAN (65-433): 1.76e-128: 416: 31.50		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Dm
		116376 M9PI41_DROME (554-1859): 9.84e-96: 347: 15.45		RHO1_DROME (1-193): 2.84e-76: 228: 86.53
+	Hs
		254464 ROCK2_HUMAN (864-1552): 1.55e-37: 157: 12.16		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		254468 ROCK2_HUMAN (864-1552): 1.55e-37: 157: 12.16		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		254433 ROCK2_HUMAN (864-1552): 1.55e-37: 157: 12.16		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Dm
		776923 Q9VXE3_DROME (682-1366): 5.51e-38: 158: 11.24		RAC1_DROME (1-193): 2.11e-77: 231: 54.12
+	Dm
		776931 X2JE40_DROME (682-1366): 6.96e-38: 158: 11.24		RAC1_DROME (1-193): 2.11e-77: 231: 54.12
+	Dm
		816384 Q961D4_DROME (682-1366): 1.1e-37: 158: 11.24		RHO1_DROME (1-193): 2.84e-76: 228: 86.53
+	Dm
		816395 X2JE40_DROME (682-1366): 6.96e-38: 158: 11.24		RHO1_DROME (1-193): 2.84e-76: 228: 86.53
+	Hs
		254462 ROCK2_HUMAN (864-1552): 1.55e-37: 157: 12.16		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		254467 ROCK2_HUMAN (864-1552): 1.55e-37: 157: 12.16		RHOB_HUMAN (1-191): 1.62e-73: 221: 83.94
+	Hs
		120238 ROCK2_HUMAN (864-1552): 1.55e-37: 157: 12.16		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98