HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: LHX4 (Q969G2)
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)
Gene: LHX4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 390
+	Hs
		152696 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25
+	Hs
		152612 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		LHX1_HUMAN (29-389): 3.38e-61: 204: 32.13
+	Hs
		152657 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		LHX8_HUMAN (24-290): 3.3e-50: 174: 29.90
+	Hs
		152615 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		LHX2_HUMAN (8-361): 5.19e-45: 162: 21.99
+	Hs
		1281184 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00
+	Hs
		1281166 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00
+	Hs
		1334137 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25
+	Hs
		1296429 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25
+	Hs
		822681 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		LHX1_HUMAN (29-389): 3.38e-61: 204: 32.13
+	Hs
		822665 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX1_HUMAN (29-389): 3.38e-61: 204: 32.13
+	Hs
		1296441 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX6_HUMAN (8-290): 1.23e-46: 165: 27.78
+	Hs
		839827 EHMT1_HUMAN (4886-5533): 1.11e-113: 399: 15.17		LHX2_HUMAN (8-361): 5.19e-45: 162: 21.99
+	Hs
		839806 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		LHX2_HUMAN (8-361): 5.19e-45: 162: 21.99
+	Hs
		1078873 ITSN1_HUMAN (3410-4271): 7.27e-97: 353: 13.54		LMO3_HUMAN (19-158): 3.93e-52: 172: 37.67
+	Hs
		203710 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		LHX8_HUMAN (24-290): 3.3e-50: 174: 29.90
+	Hs
		903721 ITSN1_HUMAN (3410-4271): 7.27e-97: 353: 13.54		LMO4_HUMAN (29-150): 2.22e-31: 118: 43.31
+	Dm
		114766 Q9W1H0_DROME (198-353): 4.05e-25: 118: 26.38		M9PD53_DROME (26-384): 1.23e-68: 227: 49.59
+	Dm
		112563 Q9W1H0_DROME (198-353): 4.05e-25: 118: 26.38		M9NCY1_DROME (26-384): 5.18e-69: 224: 49.59
+	Dm
		1368403 Q9W1H0_DROME (198-353): 4.05e-25: 118: 26.38		Q9VJ37_DROME (23-371): 4.09e-45: 164: 22.44
+	Dm
		954993 Q9W1H0_DROME (198-353): 4.05e-25: 118: 26.38		P92031_DROME (23-371): 6.08e-45: 164: 22.20