HitPredict

Interactor 1: PUB3 (O14326)
E3 ubiquitin-protein ligase pub3 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase pub3)
Gene: PUB3

Interactor 2: UBC4 (P46595)
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)
Gene: UBC4

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	26771498
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 786 Sp			1 147
+	Sc
		585709 RSP5_YEAST (5-786): 0: 757: 54.73		UBC4_YEAST (3-147): 3.41e-80: 234: 83.45
+	Sc
		585751 RSP5_YEAST (5-786): 0: 757: 54.73		UBC5_YEAST (3-147): 1.01e-79: 233: 82.76
+	Hs
		132395 WWP2_HUMAN (29-786): 0: 738: 36.77		UB2D4_HUMAN (1-147): 3.88e-84: 244: 83.67
+	Hs
		131839 WWP2_HUMAN (29-786): 0: 738: 36.77		UB2D1_HUMAN (1-147): 3.15e-83: 242: 79.59
+	Hs
		131913 WWP2_HUMAN (29-786): 0: 738: 36.77		UB2D2_HUMAN (1-147): 5.82e-83: 241: 84.35
+	Hs
		131878 WWP2_HUMAN (29-786): 0: 738: 36.77		UB2D3_HUMAN (1-147): 6.22e-82: 239: 84.35
+	Hs
		906781 WWP1_HUMAN (4-786): 0: 728: 32.62		UB2D1_HUMAN (1-147): 3.15e-83: 242: 79.59
+	Hs
		982320 WWP1_HUMAN (4-786): 0: 728: 32.62		UB2D2_HUMAN (1-147): 5.82e-83: 241: 84.35
+	Hs
		957197 WWP1_HUMAN (4-786): 0: 728: 32.62		UB2D3_HUMAN (1-147): 6.22e-82: 239: 84.35
+	Hs
		132240 WWP2_HUMAN (29-786): 0: 738: 36.77		UB2E2_HUMAN (4-146): 3.47e-75: 224: 66.43
+	Hs
		132213 WWP2_HUMAN (29-786): 0: 738: 36.77		UB2E3_HUMAN (4-146): 1.25e-74: 223: 66.43
+	Hs
		906788 SMUF2_HUMAN (3-786): 0: 717: 35.27		UB2D1_HUMAN (1-147): 3.15e-83: 242: 79.59
+	Hs
		982327 SMUF2_HUMAN (3-786): 0: 717: 35.27		UB2D2_HUMAN (1-147): 5.82e-83: 241: 84.35
+	Hs
		131840 WWP2_HUMAN (29-786): 0: 738: 36.77		UB2E1_HUMAN (4-146): 3.68e-73: 218: 66.43
+	Hs
		957205 SMUF2_HUMAN (3-786): 0: 717: 35.27		UB2D3_HUMAN (1-147): 6.22e-82: 239: 84.35
+	Hs
		906748 ITCH_HUMAN (144-786): 0: 706: 42.38		UB2D1_HUMAN (1-147): 3.15e-83: 242: 79.59
+	Hs
		982287 ITCH_HUMAN (144-786): 0: 706: 42.38		UB2D2_HUMAN (1-147): 5.82e-83: 241: 84.35
+	Hs
		957169 ITCH_HUMAN (144-786): 0: 706: 42.38		UB2D3_HUMAN (1-147): 6.22e-82: 239: 84.35
+	Hs
		1381184 ITCH_HUMAN (144-786): 0: 706: 42.38		UB2E3_HUMAN (4-146): 1.25e-74: 223: 66.43
+	Hs
		909375 ITCH_HUMAN (144-786): 0: 706: 42.38		UB2E1_HUMAN (4-146): 3.68e-73: 218: 66.43