HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: ARI2 (O95376)
E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (Triad1 protein)
Gene: ARIH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 535 Hs			1 493
+	Hs
		155981 SOCS6_HUMAN (1-535): 0: 714: 100.00		PRKN_HUMAN (113-330): 5.62e-52: 184: 22.93
+	Hs
		557371 SRC_HUMAN (258-495): 1.88e-51: 185: 15.32		CUL9_HUMAN (64-470): 5.32e-116: 377: 26.08
+	Hs
		440672 FYN_HUMAN (321-506): 1.75e-51: 185: 15.39		RNF31_HUMAN (121-374): 1.48e-58: 210: 19.85
+	Hs
		240523 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		PRKN_HUMAN (113-330): 5.62e-52: 184: 22.93
+	Hs
		240524 LYN_HUMAN (266-495): 8.96e-47: 172: 14.05		PRKN_HUMAN (113-330): 5.62e-52: 184: 22.93
+	Hs
		155961 SOCS3_HUMAN (372-533): 7.67e-38: 140: 26.56		RNF31_HUMAN (121-374): 1.48e-58: 210: 19.85
+	Hs
		136403 P85B_HUMAN (380-491): 1.9e-14: 78.2: 27.68		RN19B_HUMAN (122-354): 5.39e-68: 233: 22.49
+	Hs
		699784 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		RN19B_HUMAN (122-354): 5.39e-68: 233: 22.49
+	Hs
		136338 P85B_HUMAN (380-491): 1.9e-14: 78.2: 27.68		R144A_HUMAN (134-351): 3.2e-57: 193: 26.22
+	Hs
		699653 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		R144A_HUMAN (134-351): 3.2e-57: 193: 26.22