HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: SNTB1 (Q13884)
Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (BSYN2) (Syntrophin-2) (Tax interaction protein 43) (TIP-43)
Gene: SNTB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ, PH~Pkinase, PDZ~SH3_2
Common GO terms	GO:0005516 - calmodulin binding GO:0005737 - cytoplasm GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 926 Hs			1 538
+	Hs
		159203 CSKP_HUMAN (1-926): 0: 973: 100.00		SNTB2_HUMAN (19-537): 3.69e-141: 420: 54.41
+	Hs
		159110 CSKP_HUMAN (1-926): 0: 973: 100.00		CSKP_HUMAN (28-512): 1.27e-73: 253: 10.90
+	Hs
		159277 CSKP_HUMAN (1-926): 0: 973: 100.00		LIN7C_HUMAN (108-197): 6.75e-30: 117: 42.22
+	Mm
		251090 CSKP_MOUSE (1-926): 0: 973: 99.89		LIN7C_MOUSE (108-197): 6.75e-30: 117: 42.22
+	Hs
		159190 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG4_HUMAN (62-203): 1.16e-23: 107: 28.57
+	Mm
		251104 CSKP_MOUSE (1-926): 0: 973: 99.89		DLG1_MOUSE (18-203): 4.29e-23: 105: 24.12
+	Hs
		159200 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG1_HUMAN (77-203): 1.17e-21: 101: 33.33
+	Hs
		159249 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG3_HUMAN (39-380): 6.2e-19: 92.7: 14.80
+	Rn
		1144009 CSKP_RAT (1-926): 0: 945: 97.73		DLG1_RAT (7-321): 5.68e-22: 102: 15.66
+	Dm
		1096800 CSKP_DROME (1-926): 0: 835: 60.38		Q9VBY7_DROME (110-197): 3.41e-30: 118: 42.05
+	Hs
		1050419 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		PALS2_HUMAN (7-474): 7.86e-69: 232: 9.98
+	Dm
		116476 M9PJD0_DROME (287-926): 2.45e-154: 500: 24.89		Q9VBY7_DROME (110-197): 3.41e-30: 118: 42.05
+	Hs
		1050418 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		LIN7C_HUMAN (108-197): 6.75e-30: 117: 42.22
+	Dm
		53140 A1Z8G0_DROME (364-925): 1.05e-151: 462: 28.95		Q9VBY7_DROME (110-197): 3.41e-30: 118: 42.05
+	Mm
		1143555 MPP2_MOUSE (347-926): 5.87e-155: 469: 37.48		DLG4_MOUSE (62-203): 1.24e-23: 107: 27.89
+	Hs
		1032762 MPP3_HUMAN (341-925): 8.25e-150: 456: 28.21		LIN7C_HUMAN (108-197): 6.75e-30: 117: 42.22
+	Mm
		292498 PALS1_MOUSE (361-925): 1.68e-148: 456: 28.01		LIN7C_MOUSE (108-197): 6.75e-30: 117: 42.22
+	Hs
		1021489 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		DLG1_HUMAN (77-203): 1.17e-21: 101: 33.33
+	Mm
		1113136 Q3UP61_MOUSE (405-923): 2.92e-146: 457: 22.06		DLG4_MOUSE (62-203): 1.24e-23: 107: 27.89
+	Dm
		53136 A1Z8G0_DROME (364-925): 1.05e-151: 462: 28.95		DLG1_DROME (46-219): 1.39e-13: 75.7: 21.23