Protein: PKHG2
Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2)

Gene: PKHG2, PLEKHG2
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q9H7P9

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0030833 - regulation of actin filament polymerization
GO:0031267 - small GTPase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955603

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.768

High

1049792

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

962495

RHOA
Transforming protein RhoA

1

20

Small-scale

0.647

High

988714

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

983578

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

12

Small-scale

0.624

High

989793

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

9

Small-scale

0.618

High

1061557

ACTN3
Alpha-actinin-3

2

13

High-throughput

0.613

High

423185

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.602

High

629164

CCNA2
Cyclin-A2

2

0

High-throughput

0.585

High

1116455

FHL1
Four and a half LIM domains protein 1

2

19

Small-scale

0.584

High

1109392

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

High-throughput

0.580

High

443523

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.536

High

668031

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.536

High

1101902

SKP2
S-phase kinase-associated protein 2

1

2

High-throughput

0.536

High

1125401

FLNC
Filamin-C

1

16

High-throughput

0.536

High

1372011

LPP
Lipoma-preferred partner

1

13

High-throughput

0.536

High

697430

DCK
Deoxycytidine kinase

1

0

High-throughput

0.513

High

948080

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

1

Small-scale

0.512

High

753934

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

1

High-throughput

0.489

High

956687

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

1

High-throughput

0.489

High

1123119

FHL2
Four and a half LIM domains protein 2

1

19

High-throughput

0.489

High

1359056

DYT2B
Dynein light chain Tctex-type protein 2B

1

1

High-throughput

0.489

High

1316458

XRN1
5'-3' exoribonuclease 1

1

3

High-throughput

0.481

High

966881

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

1114316

CUL3
Cullin-3

1

8

High-throughput

0.479

High

73658

B2R8Y4
cDNA, FLJ94117, highly similar to Homo sapiens actinin, alpha 3

1

13

High-throughput

0.470

High

391462

FRIL
Ferritin light chain

1

1

High-throughput

0.445

High

1152471

T22D1
TSC22 domain family protein 1

1

4

Small-scale

0.445

High

613183

EGR1
Early growth response protein 1

1

2

High-throughput

0.437

High

1278569

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

3

High-throughput

0.407

High

1390165

MCRS1
Microspherule protein 1

1

0

High-throughput

0.279

Low

1435893

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025