HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	39115278
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 695 Hs			1 1620
+	Hs
		1371477 DVL3_HUMAN (1-695): 7.12e-154: 464: 61.00		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		159917 DVL2_HUMAN (3-695): 8.29e-141: 431: 55.98		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		936484 AFAD_HUMAN (246-658): 1.92e-82: 288: 20.83		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1091597 DLG1_HUMAN (23-634): 3e-55: 205: 15.43		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Mm
		900709 DVL1_MOUSE (1-695): 0: 561: 94.83		MUSK_MOUSE (983-1391): 3.24e-116: 390: 30.56
+	Hs
		159506 DVL2_HUMAN (3-695): 8.29e-141: 431: 55.98		FGFR3_HUMAN (952-1449): 2.13e-119: 397: 26.31
+	Mm
		581975 DVL1_MOUSE (1-695): 0: 561: 94.83		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		710800 AFAD_HUMAN (246-658): 1.92e-82: 288: 20.83		EPHB2_HUMAN (938-1436): 1.28e-127: 427: 23.26
+	Mm
		581988 DVL3_MOUSE (1-695): 5.68e-153: 462: 60.72		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		412388 DVL3_HUMAN (1-695): 7.12e-154: 464: 61.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		159463 DVL2_HUMAN (3-695): 8.29e-141: 431: 55.98		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		159498 DVL2_HUMAN (3-695): 8.29e-141: 431: 55.98		FER_HUMAN (1101-1377): 1.54e-59: 223: 40.35
+	Mm
		1222817 DLG4_MOUSE (104-626): 6.87e-57: 207: 17.60		ERBB4_MOUSE (882-1541): 6.8e-121: 414: 21.23
+	Hs
		1091498 DLG1_HUMAN (23-634): 3e-55: 205: 15.43		ERBB4_HUMAN (882-1541): 4.43e-121: 415: 22.42
+	Hs
		1006062 DLG4_HUMAN (104-626): 4.32e-56: 205: 17.42		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		411658 AFAD_HUMAN (246-658): 1.92e-82: 288: 20.83		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Mm
		582015 AFAD_MOUSE (246-658): 5.47e-80: 280: 20.14		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Mm
		581992 DLG4_MOUSE (104-626): 6.87e-57: 207: 17.60		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		411836 DLG1_HUMAN (23-634): 3e-55: 205: 15.43		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1091505 DLG1_HUMAN (23-634): 3e-55: 205: 15.43		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03