HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	39115278, 34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042127 - regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 1620
+	Hs
		159409 DVL1_HUMAN (11-736): 8.13e-163: 488: 56.04		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1371477 DVL3_HUMAN (11-736): 5.52e-160: 481: 64.77		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1091597 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		159506 DVL2_HUMAN (1-736): 0: 545: 100.00		FGFR3_HUMAN (952-1449): 2.13e-119: 397: 26.31
+	Mm
		900709 DVL1_MOUSE (11-736): 2.67e-170: 507: 57.32		MUSK_MOUSE (983-1391): 3.24e-116: 390: 30.56
+	Hs
		159463 DVL2_HUMAN (1-736): 0: 545: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		159498 DVL2_HUMAN (1-736): 0: 545: 100.00		FER_HUMAN (1101-1377): 1.54e-59: 223: 40.35
+	Mm
		581975 DVL1_MOUSE (11-736): 2.67e-170: 507: 57.32		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Mm
		581988 DVL3_MOUSE (11-736): 8.4e-159: 478: 64.91		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		412388 DVL3_HUMAN (11-736): 5.52e-160: 481: 64.77		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1091498 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		ERBB4_HUMAN (882-1541): 4.43e-121: 415: 22.42
+	Hs
		1145761 DLG3_HUMAN (80-706): 1.07e-73: 257: 14.63		ERBB4_HUMAN (882-1541): 4.43e-121: 415: 22.42
+	Hs
		1006068 DLG4_HUMAN (112-707): 3.91e-72: 250: 15.95		ERBB4_HUMAN (882-1541): 4.43e-121: 415: 22.42
+	Mm
		1222817 DLG4_MOUSE (112-707): 3.19e-72: 251: 16.27		ERBB4_MOUSE (882-1541): 6.8e-121: 414: 21.23
+	Hs
		1125290 DLG3_HUMAN (80-706): 1.07e-73: 257: 14.63		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		1006062 DLG4_HUMAN (112-707): 3.91e-72: 250: 15.95		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		411836 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1091505 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03
+	Mm
		581992 DLG4_MOUSE (112-707): 3.19e-72: 251: 16.27		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		1006074 DLG4_HUMAN (112-707): 3.91e-72: 250: 15.95		NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44