HitPredict

Interactor 1: DVL3 (Q92997)
Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)
Gene: DVL3

Interactor 2: ALK (Q9UM73)
ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene: ALK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	39115278, 34273398
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 716 Hs			1 1620
+	Hs
		159409 DVL1_HUMAN (1-716): 1.2e-144: 440: 63.38		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		159917 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1006121 DLG4_HUMAN (96-628): 3.36e-52: 195: 13.98		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Hs
		1091597 DLG1_HUMAN (17-656): 2.84e-48: 185: 13.51		ALK_HUMAN (1-1620): 0: 1901: 100.00
+	Mm
		900709 DVL1_MOUSE (1-716): 1.9e-150: 455: 62.55		MUSK_MOUSE (983-1391): 3.24e-116: 390: 30.56
+	Hs
		159506 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		FGFR3_HUMAN (952-1449): 2.13e-119: 397: 26.31
+	Mm
		581988 DVL3_MOUSE (1-716): 4.43e-167: 499: 99.02		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		412388 DVL3_HUMAN (1-716): 6.43e-168: 501: 100.00		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Mm
		581975 DVL1_MOUSE (1-716): 1.9e-150: 455: 62.55		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		159463 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		159498 DVL2_HUMAN (3-716): 2.28e-126: 394: 64.82		FER_HUMAN (1101-1377): 1.54e-59: 223: 40.35
+	Hs
		1006068 DLG4_HUMAN (96-628): 3.36e-52: 195: 13.98		ERBB4_HUMAN (882-1541): 4.43e-121: 415: 22.42
+	Mm
		1222817 DLG4_MOUSE (96-628): 1.46e-52: 195: 14.34		ERBB4_MOUSE (882-1541): 6.8e-121: 414: 21.23
+	Hs
		1091498 DLG1_HUMAN (17-656): 2.84e-48: 185: 13.51		ERBB4_HUMAN (882-1541): 4.43e-121: 415: 22.42
+	Hs
		1145735 DLG2_HUMAN (39-655): 1.2e-47: 183: 13.78		ERBB4_HUMAN (882-1541): 4.43e-121: 415: 22.42
+	Hs
		1006062 DLG4_HUMAN (96-628): 3.36e-52: 195: 13.98		FAK2_HUMAN (1054-1518): 3.57e-109: 374: 27.45
+	Hs
		1006074 DLG4_HUMAN (96-628): 3.36e-52: 195: 13.98		NTRK2_HUMAN (1093-1375): 7.39e-64: 236: 41.44
+	Mm
		581992 DLG4_MOUSE (96-628): 1.46e-52: 195: 14.34		NTRK2_MOUSE (1093-1379): 6.23e-64: 236: 41.22
+	Hs
		411836 DLG1_HUMAN (17-656): 2.84e-48: 185: 13.51		NTRK1_HUMAN (1111-1392): 5.08e-62: 230: 42.07
+	Hs
		1091505 DLG1_HUMAN (17-656): 2.84e-48: 185: 13.51		NTRK3_HUMAN (1093-1375): 2.7e-59: 223: 39.03