HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: RAP1B (P61224)
Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Gene: RAP1B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	28119087
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 184
+	Hs
		159599 DVL2_HUMAN (1-736): 0: 545: 100.00		RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55
+	Hs
		159457 DVL2_HUMAN (1-736): 0: 545: 100.00		RASH_HUMAN (1-167): 1.23e-55: 175: 57.49
+	Hs
		988325 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55
+	Hs
		976235 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		RB11A_HUMAN (4-178): 2.13e-69: 211: 28.98
+	Mm
		988891 DLG4_MOUSE (112-707): 3.19e-72: 251: 16.27		RAC1_MOUSE (1-184): 1.74e-77: 231: 27.55
+	Mm
		1223680 DLG4_MOUSE (112-707): 3.19e-72: 251: 16.27		RAB14_MOUSE (4-178): 7.99e-69: 209: 33.52
+	Hs
		374556 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		RASH_HUMAN (1-167): 1.23e-55: 175: 57.49
+	Hs
		375465 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		RASK_HUMAN (1-167): 6.29e-55: 174: 57.49
+	Hs
		373904 DLG1_HUMAN (94-707): 5.24e-82: 281: 15.94		RASN_HUMAN (1-167): 5.05e-54: 171: 56.89
+	Mm
		959453 DLG4_MOUSE (112-707): 3.19e-72: 251: 16.27		RAP2B_MOUSE (1-184): 1.47e-65: 200: 61.41
+	Hs
		374826 DLG3_HUMAN (80-706): 1.07e-73: 257: 14.63		RASH_HUMAN (1-167): 1.23e-55: 175: 57.49
+	Hs
		375800 DLG3_HUMAN (80-706): 1.07e-73: 257: 14.63		RASK_HUMAN (1-167): 6.29e-55: 174: 57.49
+	Hs
		936289 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		RAP1A_HUMAN (1-184): 1.03e-69: 211: 95.11
+	Hs
		518590 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		RAP2A_HUMAN (1-166): 6.93e-61: 188: 65.66
+	Hs
		936407 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		RIT1_HUMAN (2-180): 8.02e-57: 179: 49.16
+	Hs
		374503 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		RASH_HUMAN (1-167): 1.23e-55: 175: 57.49
+	Hs
		375325 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		RASK_HUMAN (1-167): 6.29e-55: 174: 57.49
+	Hs
		936429 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		RIT2_HUMAN (2-178): 1.4e-54: 174: 46.89
+	Hs
		373859 AFAD_HUMAN (256-712): 5.05e-48: 186: 21.41		RASN_HUMAN (1-167): 5.05e-54: 171: 56.89
+	Hs
		374277 NEB1_HUMAN (93-347): 4.81e-43: 170: 17.58		RASN_HUMAN (1-167): 5.05e-54: 171: 56.89