HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	18445679, 21362618
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 551
+	Hs
		159900 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15
+	Hs
		160216 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA6_HUMAN (27-329): 1.79e-46: 177: 16.08
+	Hs
		159891 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		IL4RA_HUMAN (1-483): 2.01e-42: 164: 17.49
+	Hs
		160004 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		EPHA7_HUMAN (27-329): 4.27e-39: 155: 14.83
+	Mm
		960493 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		IL6RB_MOUSE (47-288): 1.34e-12: 72.7: 14.17
+	Hs
		277152 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA6_HUMAN (27-329): 1.79e-46: 177: 16.08
+	Hs
		665621 ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76		EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15
+	Hs
		277067 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		EPHA7_HUMAN (27-329): 4.27e-39: 155: 14.83
+	Hs
		1072532 ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76		EPHA7_HUMAN (27-329): 4.27e-39: 155: 14.83
+	Hs
		313540 ZFYV9_HUMAN (155-489): 1.2e-38: 157: 20.63		EPHA7_HUMAN (27-329): 4.27e-39: 155: 14.83