Protein: LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2)

Gene: LRFN1
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q9P244

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0009986 - cell surface
GO:0098839 - postsynaptic density membrane
GO:0099151 - regulation of postsynaptic density assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1128966

I13R2
Interleukin-13 receptor subunit alpha-2

2

10

High-throughput

0.811

High

1452317

SCN3B
Sodium channel regulatory subunit beta-3

2

3

High-throughput

0.811

High

627582

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

2

4

High-throughput

0.789

High

688636

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

20

High-throughput

0.691

High

749414

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

1

High-throughput

0.691

High

1177251

MICA
MHC class I polypeptide-related sequence A

1

5

High-throughput

0.691

High

1245273

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

1

18

High-throughput

0.691

High

1454252

CLC4A
C-type lectin domain family 4 member A

1

18

High-throughput

0.691

High

1251815

S39A5
Zinc transporter ZIP5

3

4

High-throughput

0.662

High

749293

CD70
CD70 antigen

1

0

High-throughput

0.656

High

749817

CADH5
Cadherin-5

2

3

High-throughput

0.628

High

1454261

PCDGD
Protocadherin gamma-B1

2

5

High-throughput

0.628

High

62170

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

20

High-throughput

0.618

High

1186240

CEA21
Cell adhesion molecule CEACAM21

1

11

High-throughput

0.618

High

1454256

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

13

High-throughput

0.618

High

363953

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

411095

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

774676

BASI
Basigin

1

13

High-throughput

0.618

High

787261

BMR1A
Bone morphogenetic protein receptor type-1A

1

13

High-throughput

0.618

High

936469

AFAD
Afadin

1

20

High-throughput

0.618

High

1090196

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

12

High-throughput

0.618

High

1092503

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.618

High

1129988

MELK
Maternal embryonic leucine zipper kinase

1

1

High-throughput

0.618

High

1401124

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.618

High

938141

ANM2
Protein arginine N-methyltransferase 2

3

1

High-throughput

0.609

High

1187227

CC50B
Cell cycle control protein 50B

2

0

High-throughput

0.602

High

1434732

CDCP1
CUB domain-containing protein 1

2

0

High-throughput

0.602

High

833436

RGS2
Regulator of G-protein signaling 2

2

0

High-throughput

0.594

High

176886

DCLK1
Serine/threonine-protein kinase DCLK1

1

0

High-throughput

0.586

High

208745

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

0

High-throughput

0.586

High

1025600

CDK16
Cyclin-dependent kinase 16

1

0

High-throughput

0.586

High

1454245

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.586

High

564937

ICAM2
Intercellular adhesion molecule 2

2

0

High-throughput

0.585

High

1336534

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.578

High

1448099

S17A5
Sialin

1

2

High-throughput

0.575

High

1454264

FLVC1
Choline/ethanolamine transporter FLVCR1

1

6

High-throughput

0.575

High

378301

IFN21
Interferon alpha-21

2

1

High-throughput

0.574

High

1159952

CCL14
C-C motif chemokine 14

2

3

High-throughput

0.574

High

1432770

TMX1
Thioredoxin-related transmembrane protein 1

2

2

High-throughput

0.574

High

1152055

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

12

High-throughput

0.553

High

1216031

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

5

High-throughput

0.553

High

1229906

AN34A
Ankyrin repeat domain-containing protein 34A

1

5

High-throughput

0.553

High

1309257

KSR1
Kinase suppressor of Ras 1

1

3

High-throughput

0.553

High

1322661

RPTOR
Regulatory-associated protein of mTOR

1

1

High-throughput

0.553

High

1396842

SNX27
Sorting nexin-27

1

5

High-throughput

0.553

High

1402222

TESK2
Dual specificity testis-specific protein kinase 2

1

2

High-throughput

0.553

High

1438850

TANC2
Protein TANC2

1

1

High-throughput

0.553

High

1454254

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.553

High

328755

VAMP5
Vesicle-associated membrane protein 5

1

1

High-throughput

0.536

High

1248405

I27RA
Interleukin-27 receptor subunit alpha

1

5

High-throughput

0.536

High

1382081

T106A
Transmembrane protein 106A

1

4

High-throughput

0.536

High

1417272

TMM59
Transmembrane protein 59

1

1

High-throughput

0.536

High

1454079

SLAF8
SLAM family member 8

1

11

High-throughput

0.536

High

1454253

TNF18
Tumor necrosis factor ligand superfamily member 18

1

1

High-throughput

0.536

High

1454262

PCDG4
Protocadherin gamma-A4

1

5

High-throughput

0.536

High

1454263

PCDA9
Protocadherin alpha-9

1

5

High-throughput

0.536

High

730309

1433B
14-3-3 protein beta/alpha

2

7

High-throughput

0.521

High

163180

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.517

High

245280

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

0

High-throughput

0.517

High

1249751

S49A3
Solute carrier family 49 member A3

1

3

High-throughput

0.514

High

460284

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

0

High-throughput

0.513

High

467636

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.513

High

1159247

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

1430699

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

49823

CLRN2
Clarin-2

1

2

High-throughput

0.489

High

219386

B4GA1
Beta-1,4-glucuronyltransferase 1

1

1

High-throughput

0.489

High

548137

PSPC
Surfactant protein C

1

4

High-throughput

0.489

High

1245933

BRID5
BRICHOS domain-containing protein 5

1

4

High-throughput

0.489

High

637966

NF1
Neurofibromin

1

3

High-throughput

0.479

High

1219628

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

1286551

PHLB2
Pleckstrin homology-like domain family B member 2

1

1

High-throughput

0.479

High

1411425

CAB45
45 kDa calcium-binding protein

1

2

High-throughput

0.479

High

1419842

OSBL6
Oxysterol-binding protein-related protein 6

1

2

High-throughput

0.479

High

1454247

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

High-throughput

0.479

High

1454255

GAB2
GRB2-associated-binding protein 2

1

3

High-throughput

0.479

High

1454260

KCTD3
BTB/POZ domain-containing protein KCTD3

1

5

High-throughput

0.479

High

269626

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

1293247

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

0

High-throughput

0.458

High

1409793

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1448820

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

1454244

CING
Cingulin

1

0

High-throughput

0.458

High

388464

B3AT
Band 3 anion transport protein

1

4

High-throughput

0.445

High

1439128

ANKH
Mineralization regulator ANKH

1

3

High-throughput

0.445

High

1454248

S39AA
Zinc transporter ZIP10

1

4

High-throughput

0.445

High

1454251

YLAT1
Y+L amino acid transporter 1

1

3

High-throughput

0.445

High

230580

KIF1C
Kinesin-like protein KIF1C

1

2

High-throughput

0.437

High

246169

KIF1B
Kinesin-like protein KIF1B

1

2

High-throughput

0.437

High

281442

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.437

High

719272

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.437

High

719379

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.437

High

941074

HDAC4
Histone deacetylase 4

1

3

High-throughput

0.437

High

966964

1433G
14-3-3 protein gamma

1

7

High-throughput

0.437

High

1145706

RCN1
Reticulocalbin-1

1

2

High-throughput

0.437

High

1216100

SPD2A
SH3 and PX domain-containing protein 2A

1

3

High-throughput

0.437

High

1234995

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.437

High

1251458

GGYF2
GRB10-interacting GYF protein 2

1

2

High-throughput

0.437

High

1257048

SYDE1
Rho GTPase-activating protein SYDE1

1

2

High-throughput

0.437

High

1272889

RFIP2
Rab11 family-interacting protein 2

1

1

High-throughput

0.437

High

1277714

MYCPP
C-myc promoter-binding protein

1

3

High-throughput

0.437

High

1349480

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1352617

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.437

High

1352638

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

2

High-throughput

0.437

High

1356774

HDAC7
Histone deacetylase 7

1

3

High-throughput

0.437

High

1357436

DEP1B
DEP domain-containing protein 1B

1

2

High-throughput

0.437

High

1360407

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.437

High

1410262

F110A
Protein FAM110A

1

1

High-throughput

0.437

High

1437673

PKHA5
Pleckstrin homology domain-containing family A member 5

1

3

High-throughput

0.437

High

1447273

KI13B
Kinesin-like protein KIF13B

1

2

High-throughput

0.437

High

1454246

NGAP
Ras GTPase-activating protein nGAP

1

3

High-throughput

0.437

High

1454258

STA13
StAR-related lipid transfer protein 13

1

1

High-throughput

0.437

High

1454259

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.437

High

1438447

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

515911

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

1330753

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.279

Low

1413148

SPXN
Spexin

1

0

High-throughput

0.279

Low

1449191

CAH10
Carbonic anhydrase-related protein 10

1

0

High-throughput

0.279

Low

252183

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.249

Low

339112

NADK
NAD kinase

1

0

High-throughput

0.249

Low

1065776

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

0

High-throughput

0.249

Low

1134072

ZN638
Zinc finger protein 638

1

0

High-throughput

0.249

Low

1187143

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.249

Low

1198351

CRTC2
CREB-regulated transcription coactivator 2

1

0

High-throughput

0.249

Low

1238319

REEP3
Receptor expression-enhancing protein 3

1

0

High-throughput

0.249

Low

1245753

LARP1
La-related protein 1

1

0

High-throughput

0.249

Low

1338120

NAV1
Neuron navigator 1

1

0

High-throughput

0.249

Low

1390419

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.249

Low

1410853

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

1412885

RTKN
Rhotekin

1

0

High-throughput

0.249

Low

1419468

PANK2
Pantothenate kinase 2, mitochondrial

1

0

High-throughput

0.249

Low

1452546

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1454067

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.249

Low

1454249

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.249

Low

1454250

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.249

Low

1454257

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025