HitPredict

Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.439

Property	Details
Experiments	31002735
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 358 Hs			1 875
+	Hs
		1050418 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		1006050 DLG4_HUMAN (88-235): 2.26e-13: 73.1: 19.36		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		1050405 DLG1_HUMAN (55-238): 6.78e-12: 68.9: 18.85		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		1050509 SNX27_HUMAN (12-91): 4.37e-09: 59.7: 37.63		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		1368713 DLG3_HUMAN (14-292): 1.13e-29: 122: 14.24		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Mm
		97734 DLG3_MOUSE (1-285): 9.86e-30: 122: 14.61		E9PXB7_MOUSE (329-873): 0: 573: 24.75
+	Hs
		132062 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Mm
		861864 DLG3_MOUSE (1-285): 9.86e-30: 122: 14.61		NEDD4_MOUSE (207-873): 1.47e-179: 542: 21.78
+	Hs
		1399986 MAGI1_HUMAN (3-318): 2.73e-18: 88.5: 15.34		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Hs
		132175 INADL_HUMAN (70-240): 6.34e-11: 66.1: 12.36		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Mm
		1223651 DLG4_MOUSE (88-235): 2.22e-13: 73.1: 19.36		NED4L_MOUSE (247-873): 0: 575: 22.37
+	Mm
		97740 DLG4_MOUSE (88-235): 2.22e-13: 73.1: 19.36		E9PXB7_MOUSE (329-873): 0: 573: 24.75
+	Hs
		1341095 INADL_HUMAN (70-240): 6.34e-11: 66.1: 12.36		WWP1_HUMAN (185-873): 0: 560: 22.22
+	Hs
		1150445 NHRF2_HUMAN (4-187): 1.29e-21: 95.9: 36.96		HUWE1_HUMAN (523-874): 5.99e-53: 203: 33.97
+	Hs
		1091527 DLG1_HUMAN (55-238): 6.78e-12: 68.9: 18.85		HUWE1_HUMAN (523-874): 5.99e-53: 203: 33.97